A novel method for identifying potential side-effects to medications through largescale analysis of clinical data is here introduced and evaluated. By calculating distributional similarities for medication-symptom pairs based on co-occurrence information in a large clinical corpus, many known adverse drug reactions are successfully identified. These preliminary results suggest that semantic vec...

 Introduction: Olanzapine (Zyprexa) has become one of the most commonly prescribed atypical antipsychotic drug in Iran, at least in part due to its low potential to cause extra-pyramidal side effects. Case: A 54-year-old man, who was a known case of schizophrenia from 10 years ago and within the recent years, was under periodic medical treatment by antipsychotic drugs. Conclusion: Neurologi...

19 19 QUESTIONS • CHALLENGES • CONTROVERSIES Dapsone, first developed in 1908, was initially intended for oral treatment of infectious diseases; however, dapsone was later shown to have potent anti-inflammatory properties. The anti-inflammatory mechanisms of dapsone appear to be separate from its antibacterial properties. Oral dapsone has been shown to be efficacious for dermatoses with neutrop...

OBJECTIVES To determine the frequency of adverse effects related to the use of the tuberculosis treatment regimen designated Regimen I and the need for regimen alterations due to these effects. METHODS A retrospective analysis of 329 medical charts of patients who were treated with Regimen I and discharged after cure between March 2000 and April 2006 was carried out at the Tuberculosis Outpat...

BACKGROUND Minor side effects associated with chiropractic are common. However, little is known about their predictors or the effects of reactions on satisfaction and clinical outcomes. OBJECTIVE The objectives of this study are to compare the relative effects of cervical spine manipulation and mobilization on adverse reactions and to estimate the effects of adverse reactions on satisfaction ...

Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Development of anti-cancer targeted therapies from biologics is increasingly being utilized. Cetuximab, a chimeric monoclonal antibody, is one such anti-cancer targeted therapeutic that has shown efficacy in quelling the rate of patient decline in colorectal, head/neck, and no...

BACKGROUND While community distribution of topical repellents has been proposed as an additional malaria control intervention, the safety of this intervention at the population level remains poorly evaluated. We describe the safety of mass distribution of the picaridin repellent during a cluster-randomised trial in rural Cambodia in 2012-2013. METHODS The repellent was distributed among 57 in...