for large and complex reacting systems, computational efficiency becomes a critical issue in process simulation, optimization and model-based control. mechanism simplification is often a necessity to improve computational speed. we present a novel approach to simplification of reaction networks that formulates the model reduction problem as an optimization problem and solves it using genetic al...

Models that aim to optimize the design of supply chain networks have gained more interest in the supply chain literature. Mixed-integer linear programming and discrete-event simulation are widely used for such an optimization problem. We present a hybrid approach to support decisions for supply chain network design using a combination of analytical and discrete-event simulation models. The prop...

high efficiency and uniformity of water and fertilizer application are usually, considered as the ultimate goals of an appropriate design and management of irrigation and fertigation systems. the objective followed in this paper was to present a simulation-optimization model for alternate vs. conventional furrow fertigation. two simulation models (surface fertigation and swms-2d models) along w...

Miminizing errors of the physical parameters of interest should be the ultimate goal of any event selection optimization in high energy physics data analysis involving parameter determination. Quick and reliable error estimation is a crucial ingredient for realizing this goal. In this paper we derive a formalism for direct evaluation of measurement errors using the signal probability density fu...

The topic of simulation–optimization has not been fundamentally tackled by many continuous-time modeling and simulation tools, yet. Common simulation-based optimization problems are usually coupled with standard optimization algorithms like any other simulation-free nonlinear optimization problems. While such couplings are usually based on many state-of-the-art software engineering concepts wit...

The bubble effectiveness in liquid phase cylohexane non-catalytic oxidation process is discussed in this paper. Then the bubble effectiveness and a new proposed kinetic model are used in the mathematical model of the industrial reactor for the cyclohexane non-catalytic oxidation process. Furthermore, simulation and optimization based on this reactor model are carried out. The results of sim...