background: immune thrombocytopenic purpura (itp) is a disease characterized by decrease of the peripheral blood platelet count. the disease presents in acute and chronic forms. because of the importance and high prevalence of itp, it was decided to study the therapeutic response of patients with itp. material and methods: a cross-sectional study was conducted at ghaem hospital, mashhad, iran. ...

Sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. It was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. It has several adverse reactions on multi organ systems including hematologic system. Although the neutropenia and thrombocytopenia commonly happens as Gra...

splenomegaly-induced thrombocytopenia is fully described in hematological and surgical literature, but its association with severe aortic stenosis is rare. we present a case of severe aortic valve stenosis with severe splenomegaly-induced thrombocytopenia in which aortic valve replacement was done with a number 23 homograft and splenectomy was performed after the end of cardiopulmonary bypass. ...

Background: Infant jaundice is one the most common causes of hospitalization in infant in the first month of birth, which is defined an abnormal increase in blood bilirubin levels. Exchange transfusion is the recommended treatment for neonatal jaundice who do not respond to phototherapy and experience dangerous complication of jaundice and signs of kernicterus. However, this treatment may lead ...

Sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. It was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. It has several adverse reactions on multi organ systems including hematologic system. Although the neutropenia and thrombocytopenia commonly happens as Gra...

conclusions the authors describe the second reported case of eptifibatide-induced severe thrombocytopenia associated with cardiac surgery. in this case, discontinuation of eptifibatide and transfusion of apheresis platelets increased the platelet count (137 k/ul) the following day, and the patient subsequently underwent successful coronary artery surgery using cardiopulmonary bypass. introducti...

severe thrombocytopenia with bleeding is rarely reported in children with brucellosis, and recurrent epistaxis is extremely rare. brucellosis with hemorrhage should be differentiated from viral hemorrhagic fever, malignancy, and other blood disorders. bone marrow aspiration (bma) is mandatory to differentiate from other blood diseases. an 8-year-old boy was admitted with recurrent epistaxis, pe...

background thrombocytopenia is associated with a bad prognosis in leptospirosis. objectives we investigated the effect of corticosteroids to improve thrombocytopenia due to leptospirosis. patients and methods in a clinical trial, all patients admitted with leptospirosis in razi hospital of ghaemshahr, north of iran were enrolled in a 2-year study. totally, 56 patients with moderate to severe th...

in systemic lupus erythematosus- (sle) various antibodies are produced against cells including platelets and result in thrombocytopenia. in the literature, the incidence of thrombocytopenia varied from 7% to 52%, in seven series of sle patients with a mean cumulative percentage of 14.5% (1-5). sle patients referred to the lupus unit of the rheumatology research center, tehran university for med...