In this study, 92% of patients' serums known to contain antibodies against islet cells, including the Juvenile Diabetes Foundation provisional reference serum, had antibodies reacting with gastrointestinal carcinoid tumors. Twelve percent of the control serums from healthy individuals bound to carcinoid cells, and 2% bound to islet cells. Seventy-five percent of the children with newly diagnose...

We generated a panel of eight rat IgG(2a) monoclonal antibodies with high affinity for mouse VEGFR2 (KDR/Flk-1), the main receptor that mediates the angiogenic effect of VEGF-A. The antibodies (termed RAFL, R at Anti Flk) bound to dividing endothelial cells more strongly than they did to nondividing cells. Most of the RAFL antibodies blocked [(125)I]VEGF(165) binding to VEGFR2. Three of eight a...

Antibodies have been shown to be a potent therapeutic tool. However, their use for targeting brain diseases, including neurodegenerative diseases and brain cancers, has been limited, particularly because the blood-brain barrier (BBB) makes brain tissue hard to access by conventional antibody-targeting strategies. In this review, we summarize new antibody therapeutic approaches to target brain t...

p53 and PCNA expression in keratocystic odontogenic tumors compared with selected odontogenic cysts Summary: The aim of this study was to evaluate p53 and PCNA expression in different odontogenic lesions regarding their different clinical behaviors. Slices prepared from 94 paraffin-embedded tissue blocks (25 radicular cysts (RC), 23 dentigerous cysts (DC), 23 keratocystic odontogenic tumors (KC...

Hu5F9-G4 and AK117, novel cluster of differentiation 47 blockers, are used to treat solid tumors hematoma. Because is expressed on erythrocytes, treatment with monoclonal anti-cluster may interfere the results transfusion compatibility testing. This study analyzed interference AK117 Saline microcolumn gel methods were identify blood types patients. To screen irregular antibodies, salt water, in...

Abstract Background Colorectal cancer (CRC) infiltration by T lymphocytes is associated with prolonged survival. However, immune spontaneously occurs in <20% of tumors and no therapies able to promote it are currently available. CRC tissue populated gut bacteria translocated across the neoplastic epithelium. We previously showed that direct contact between tumor cells induces overexpress...

In the early investigations into the nature of the etiologic agent of fowl tumors, immunity phenomena were given some attention. The first observation was that the manifestations of resistance to these tumors in fowls, whether natural or acquired, are similar to those established for mammalian tumors, the principal feature being a local cellular reaction about the introduced graft (1). As was a...

background: antiphospholipid antibodies (apl) are a heterogeneous family of anti-bodies associated with thrombosis and other complications. objective: to study the prevalence of apl in patients with thrombosis at aleppo university hospitals, syria. methods: one hundred and fifty-seven patients with venous and arterial thrombosis and 63 healthy controls were studied. anticardiolipin antibodies (...