Optimum control of upstream pumping station in open channels with given constraint in downstream end is presented in this paper. The upstream control is capable of minimizing water level fluctuations in the channel in which the downstream pumping station causes an undesirable wave. The proposed method combines an unsteady non-uniform flow solver with shock-capturing capability, Fourier series a...

The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work in the last decade clearly demonstrates that TOR controls protein synthesis through a stunning number of downstream targets. Some of the targets are phosphorylated directly by TOR, but many are phosphory...

background: groundwater is the most important source of water supply in industries and agricultures; therefore the need to protect this valuable resource against pollution is felt more than ever. in this study, the possible impact of yazd municipal solid waste landfill was investigated on the chemical quality of the area’s groundwater. methods: groundwater samples were collected from three well...

Blinatumomab, the bispecific T cell engager, has been demonstrated as the most successful BsAb to date. Throughout the past decade, vector design has great importance for the expression of monoclonal antibody in Chinese hamster ovary (CHO) cells. It has been indicated that expression plasmids based on the elongation factor-1 alpha (EF-1 alpha) gene and DHFR selection marker can be highly effect...