Dendritic cell (DC)-based vaccination is a promising strategy for cancer immunotherapy. However, clinical trials have indicated that immunosuppressive microenvironments induced by tumors profoundly suppress antitumor immunity and inhibit vaccine efficacy, resulting in insufficient reduction of tumor burdens. To overcome these obstacles and enhance the efficiency of DC vaccination, we generated ...

Interleukin-12 (IL12) enhances anti-tumor immunity when delivered to the tumor microenvironment. However, local immunoregulatory elements dampen the efficacy of IL12. The identity of these local mechanisms used by tumors to suppress immunosurveillance represents a key knowledge gap for improving tumor immunotherapy. From a systems perspective, local suppression of anti-tumor immunity is a close...

The aim of this study was the analysis of the cytokine response in BALB/c mice infected with the highly virulent RH or the weakly virulent Beverley strains of Toxoplasma gondii. Analysis of cytokine messages showed increased expression of IL12, IFN-gamma and TNF-alpha, but not IL4 mRNAs in spleen cells after infection with the T. gondii strains RH and Beverley. High levels of circulating IL12 a...

this study investigated the in vitro production of interferon-γ, interleukin (il)-10, il-12, and il-13, after antigenic stimulation of the cells (with leishmania antigen and lipopolysaccharide) using whole blood from patients with cutaneous leishmaniasis lesions caused by leishmania tropica and in volunteers with history of cutaneous leishmaniasis. elisa results showed that the mean production ...

Proinflammatory cytokines have been used for several years in patients with advanced cancer but their administration is typically associated with severe toxicity hampering their application to therapeutically active regimens. This problem can be overcome by using immunocytokines (cytokines fused to antibody or antibody fragments) which selectively deliver the active cytokine to the tumor enviro...

BACKGROUND The identification of biomarkers of transition from the at-risk mental state (ARMS) to psychotic disorder is important because early treatment of psychosis is associated with improved outcome. Increasing evidence points to an inflammatory contribution to psychosis. We questioned whether raised levels of plasma inflammatory markers predict transition from ARMS to psychotic disorder an...

Cousens, LP, Orange, J.S. & Biron, CA. (1995), EndogeWysocka, M., Kubin, M., Vieria, L.Q., Ozmen, L., nous interleukin-2 (IL-2) contributes to T cell expanGarotta, G., Scott, P. & Trinchieri, G. (1995), Intersion and interferon y (IFN-y) production during leukin-12 is required for interferon-y production and lymphocytic choriomeningitis virus infection. J. lethality in lipopolysaccharide-induce...