Background and Purpose: Oral administrations have been used for many years as a main method comparing to other methods. Sustained release techniques have been a great interest recently. Matrix polymers are one of the ways used to prepare a sustained-release drug and are most widely used to prepare the controlled-release drugs. Cellulose derivatives are the most common ones. Solubilities of so...

سابقه و هدف: کلپوره گیاه دارویی است که اثرات ضد دیابت، ضد چربی خون، ضد میکروبی و کاهش دهنده فشار خون آن گزارش شده است، هدف از این تحقیق، بررسی اثرات اینوتروپیک و کرونوتروپیک عصاره آبی – الکلی کلپوره بر قلب ایزوله خوکچه هندی می باشد مواد و روشها: این مطالعه تجربی بر روی 24 خوکچه هندی نژاد dunkin hartly (450-350 گرم) صورت گرفته است. حیوانات بطور تصادفی به سه گروه 8 تایی، گروه اول (کربس کلسیم دار)...

Background & Objective: Verapamil, nifedipine and diltiazem are calcium channel blockers widely used as a variety of cardiovascular ailment in humans. A number of studies have shown that calcium channel blockers have anticonvulsant effect in a range of animal seizure models (but not all animals). The aim of this study was to investigate the effects of verapamil, nifedipine and diltiazem on pe...

Abstract Background and purpose: The dissolution of a drug has an important role in its bioavailability. Any change in the physico-chemical properties can result in changes in the drug release, and furthermore in its bioavailability. In order to overcome such changes, it is necessary to determine the storage conditions required for obtaining a desired drug release. Materials and methods: Di...

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Introduction: In this randomized prospective study, 2% - diltiazem topical gel and 0.03% -GTN ointment were compared in patients with chronic anal fissure. Methods: This semi-experimental study consisted of sixty six outpatients (34 females and 32 males) with chronic anal fissure, who referred to the gastroenterology clinic. Patients were randomly classified into two groups. Group A received G...

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