Candida krusei is an important agent of opportunistic infections that often displays resistance to several antifungals. We describe here the in vivo acquisition of resistance to voriconazole (VRC) by C. krusei isolates recovered from a leukemia patient during a long period of VRC therapy. In order to mimic the in vivo development of VRC resistance, a susceptible C. krusei isolate was exposed da...

Aim: To evaluate fluconazole resistance among C. tropicalis by broth micro dilution methodand relative expression of ergosterol(ERG11) gene in resistant and sensitive Candida tropicalis. Methods: The study design was comparative conducted inMicrobiology Department UHS.A sum up 66 confirmed isolates Candidatropicalis were attained from Jinnah Hospital, Lahore. fluconazoleresistance the determine...

The widespread use of antifungal agents has led to increasing azole resistance in Candida species. A major azole-resistance mechanism involves point mutations in the ERG11 gene, which encodes cytochrome P450 lanosterol 14a-demethylase. In this study, vaginal swabs were obtained from 657 pregnant Chinese Han women and cultured appropriately. The open reading frame of the obtained fungal species ...

Isavuconazole is a novel, broad-spectrum, antifungal azole. In order to evaluate its interactions with known azole resistance mechanisms, isavuconazole susceptibility among different yeast models and clinical isolates expressing characterized azole resistance mechanisms was tested and compared to those of fluconazole, itraconazole, posaconazole, and voriconazole. Saccharomyces cerevisiae expres...

BACKGROUND A major characteristic of Candida biofilm cells that differentiates them from free-floating cells is their high tolerance to antifungal drugs. This high resistance is attributed to particular biofilm properties, including the accumulation of extrapolymeric substances, morphogenetic switching, and metabolic flexibility. OBJECTIVES This study evaluated the roles of metabolic processe...

Background and Purpose: Candida albicans is the most common Candida species (spp.) isolated from fungal infections. Azole resistance in Candida species has been considerably increased in the last decades. Given the toxicity of the antimicrobial drugs, resistance to antifungal agents, and drug interactions, the identification of new antifungal agents seems essential. In this study, we assessed t...

Opportunistic fungal infections resistant to antifungal agents have been increasingly documented in recent years and their frequency will likely continue to increase. This phenomenon appears due largely to the extensive use of antifungal agents to treat fungal infections that typically occur in severely immunocompromised and/or critically ill patients. Candida species are leading fungi responsi...