Profiling of microRNA expression in human cancers has highlighted downregulation of miR-145 as a common event in epithelial malignancies. Here, we describe recurrent underexpression of miR-145 in hepatocellular carcinoma (HCC) and the identification of a biological pathway by which miR-145 exerts its functional effects in liver tumorigenesis. In a cohort of 80 HCC patients, quantitative reverse...

Ganoderma lucidum, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to promote health and longevity. Compounds extracted from G. lucidum have revealed anticancer, antioxidant and liver protective effects. G. lucidum has been associated with prostate cancer cells. G. lucidum extracts contain numerous bioactive components; however, the exact f...

Results: Many differences are observed regarding the consumption of beverages in Spain, between the 60`s and 2014. Consumption of alcoholic beverages has decreased (50% -1964: 145 g/person/day; 1991: 113 g/person/day; 2000: 78.4 g/person/day and 2014: 72.6 g/person/day-) and consumption of non-alcoholic has increased (721 % -1964: 46 g/person/day; 1991: 96 g/person/day; 2000: 240 g/person/day a...

soda and soda-aq pulping of corn stalk applying different charges of active alkali and pulping time was studied. the average value of fiber length, diameter and cell wall thickness were measured as 1.03 mm, 23.64 µm and 5.26 µm, respectively. the content of alcohol-acetone extractives, cellulose, lignin, extractives soluble in 1% naoh and ash content of corn stalk were determined as 15%, 51.2%,...

To facilitate structure-function relationship studies of the V2 vasopressin receptor, a prototypical G(s)-coupled receptor, we generated V2 receptor-expressing yeast strains (Saccharomyces cerevisiae) that required arginine vasopressin-dependent receptor/G protein coupling for cell growth. V2 receptors heterologously expressed in yeast were unable to productively interact with the endogenous ye...

BACKGROUND. Clinical symptoms of prostatitis, prostatodynia, and benign prostatic hyperplasia are relieved by the pollen extract cernilton, and the water-soluble fraction of this extract selectively inhibits growth of some prostate cancer cells. A cyclic hydroxamic acid, DIBOA, has been isolated from this extract and mimics its cell growth-inhibitory properties, but the specificity of DIBOA for...