نتایج جستجو برای: 367 low
تعداد نتایج: 1204447 فیلتر نتایج به سال:
BACKGROUND Metastasis is one of the main reasons for treatment failure in endometrial cancer. Notably, high mobility group AT-hook 2 (HMGA2) has been recognized as a driving factor of tumour metastasis. microRNAs (miRNAs) are powerful posttranscriptional regulators of HMGA2. METHODS The binding sites of miR-302a-5p and miR-367-3p on HMGA2 mRNA were identified using bioinformatics prediction s...
A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice.
In contrast to lower vertebrates, the mammalian heart has limited capacity to regenerate after injury in part due to ineffective reactivation of cardiomyocyte proliferation. We show that the microRNA cluster miR302-367 is important for cardiomyocyte proliferation during development and is sufficient to induce cardiomyocyte proliferation in the adult and promote cardiac regeneration. In mice, lo...
In medulloblastoma, abnormal expression of pluripotency factors such as LIN28 and OCT4 has been correlated with poor patient survival. The miR-302/367 cluster has also been shown to control self-renewal and pluripotency in human embryonic stem cells and induced pluripotent stem cells, but there is limited, mostly correlational, information about these pluripotency-related miRNA in cancer. We ev...
Background: Postoperative morbidity in patients with obstructive jaundice remains high because of increased susceptibility to endotoxin and the inflammatory cascade. Aims: An experimental study was designed to investigate the efficacy of protegrin peptide IB-367, an antimicrobial positively charged peptide, in neutralising Escherichia coli 0111:B4 lipopolysaccharide (LPS) in bile duct ligated r...
abstract the present study was conducted to examine the effect of proficiency on students interaction while carrying out the grammar-based task(s) in collaboration. in particular, the study examines whether the level of proficiency affects the learners’ focus of attention to grammatical and lexical features. the study takes a further step and examines whether there is any difference in the use...
مقدمه: از آن¬جایی که ظرفیت سیستم اعصاب مرکزی (cns) برای ترمیم محدود است؛ محققان برآنند تا پتانسیل ترمیم cns را از طریق رویکردهای مختلف افزایش دهند. اخیرا برخی از مطالعات بیانگر این هستند که آستروسیت¬ها می¬توانند به نوروبلاست و نورون در شرایط in vivo بازبرنامه ریزی گردند. در این مطالعه ما نشان می¬دهیم که تزریق mir-302/367 به عنوان microrna اختصاصی سلول¬های بنیادی عصبی با والپروات در استریاتوم و ...
In eukaryotes, the origin recognition complex (ORC) heterohexamer preferentially binds replication origins to trigger initiation of DNA replication. Crystallographic studies using eubacterial and archaeal ORC orthologs suggested that eukaryotic ORC may bind to origin DNA via putative winged-helix DNA-binding domains and AAA+ ATPase domains. However, the mechanisms how eukaryotic ORC recognizes ...
Glutamate transporters located in the brain maintain low synaptic concentrations of the neurotransmitter by coupling its flux to that of sodium and other cations. In the binding pocket of the archeal homologue Glt(Ph), a conserved methionine residue has been implicated in the binding of the benzyl moiety of the nontransportable substrate analogue threo-beta-benzyloxyaspartate. To determine whet...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Shpudeiko V, Sokolov K, Sidaruk H. Artificial intelligence in solving dermatological problems. Dermatology Review/Przegląd Dermatologiczny. 2022;109(5):361-367. doi:10.5114/dr.2022.125685. APA Shpudeiko, V., Sokolov, K., & Sidaruk, (2022). Dermatologiczny, 109(5), 361-367. https://doi.org/10.5114/dr.2022.125685 Ch...
The prognosis is generally poor for patients who experience a cardiac arrest. Abstract The most common causes of sudden cardiac arrest are massive pulmonary embolism (PE) and acute myocardial infarction (MI). While thrombolysis is a first-line treatment option in massive PE and acute MI, cardiopulmonary resuscitation (CPR) has been regarded as a relative contraindication for thrombolysis becaus...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید