Tyrosinase serves as a key enzyme in the synthesis of melanin. In humans mutations in the TYR gene are associated with type 1 oculocutaneous albinism (OCA1) that leads to reduced or absent pigmentation of skin, hair and eye. Various mutations causing OCA in man, mouse, rabbit and cattle have been identified throughout the Tyrosinase gene including nonsense, missense, frameshift and splice site ...

The innervation of the anterior segment of the albino rabbit eye was studied with both the histofluorometric technique of Falck for adrenergic fibers and the thiocholine method for cholinergic fibers. Adrenergic fibers were found in heavy concentration in the iris dilator, ciliary processes, and around blood vessels. In lesser number adrenergic fibers were seen in the cornea and filtration area...

Croton tiglium used as a cathartic in Ayurvedic system of indigenous medicine, was investigated for its effects in experimental animals. 50% EtOH extract of the dried nuts of the plant was used of the study. The extract exhibited a dose dependent cathartic effect in albino rats, the extract also showed an increase to gut movement with an increased contractile movement on rabbit jejunum, partial...

The present report describes outbreaks of viral hemorrhagic disease in domestic rabbits. The provisional diagnosis was reached by feature of postmortem lesions and result of experimental inoculation of liver homogenate in adult and juvenile albino laboratory rabbits. The presence of etiologic agent in the homogenate from spontaneous and experimentally infected rabbits was demonstrated by agglut...

Purpose To determine the presence of monocarboxylate transporter (MCT) in human and rabbit corneal epithelium and its role in transcellular fluorescein transportation in the cornea. Methods The presence of MCTs in human and rabbit corneal epithelium was determined by RT-PCR and immunohistochemistry. Intracellular fluorescein uptake experiment was performed using cultured human corneal epithel...

Objective(s): Silver nanoparticles have been widely used as new potent antimicrobial agents in cosmetic and hygienic products, as well as in new medical devices. Serious concerns have been expressed on the potential health risks of dermal applications of nanosilver containing consumer products (AgNPs), therefore regulatory health risk assessment has become necessary for the saf...

This study was carried out in order to compare the oral mucosal reactions to silk and poly vinylidene fluoride (PVDF) suture materials in albino rabbit. Twenty-one mature male albino rabbits were selected and under general and local anesthesia suture materials were placed randomly at right and left side of vestibular area of maxillary jaw. The animals were divided into three equal groups based ...

The albino rat retina is severely damaged by exposure to bright light. The degree of damage depends upon the intensity of the exposure and its duration. In the present study, electroretinographic (ERG) responses were measured in rats exposed at different ages during the period of retinal development to 24 hr of bright light and then transferred to darkness for about 2 months. The ERG data indic...