Abstract Non-small cell lung cancer (NSCLC) is one of the most lethal malignant tumors. It has been shown that general anesthetic agents, propofol and astragaloside IV (AS-IV) both exert antitumor effects in NSCLC. However, combination with AS-IV NSCLC remain unclear. Cell counting kit-8, EdU Transwell assays were performed to evaluate viability, proliferation, migration. apoptosis autophagy ob...

Cisplatin is one of the most used first-line anticancer drugs for various solid tumor therapies. However, cisplatin-based chemotherapy can induce cells to secrete excessive prostaglandin E2 (PGE2) catalyzed by cyclooxygenase-2 (COX-2), which, in turn, counteracts its chemotherapeutic effect and further accelerates metastasis. Here, we report a carrier-free self-delivered nanoprodrug based on pl...

Defects in apoptotic pathways can promote cancer cell survival and also confer resistance to antineoplastic drugs. One pathway being targeted for antineoplastic therapy is the anti-apoptotic B-cell lymphoma-2 (Bcl-2) family of proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1, Bfl1/A-1, and Bcl-B) that bind to and inactivate BH3-domain pro-apoptotic proteins. Signals transmitted by cellular damage (includi...

In the human body, billions of cells die by apoptosis every day. The subsequent clearance of apoptotic cells by phagocytosis is normally efficient enough to prevent secondary necrosis and the consequent release of cell contents that would induce inflammation and trigger autoimmunity. In addition, apoptotic cells generally induce an anti-inflammatory response, thus removal of apoptotic cells is ...

Cardiosphere-derived cells (CDCs) have emerged as one of the most promising stem cell types for cardiac protection and repair. Exosomes are required for the regenerative effects of human CDCs and mimic the cardioprotective benefits of CDCs such as anti-apoptotic effect in animal myocardial infarction (MI) models. Here we aimed to investigate the anti-apoptotic effect of the hypoxic and normoxic...

Betulinic acid, BA, is a lupane derivative that has caught the interest of researchers due to wide variety pharmacological properties it exhibits towards tumor cells. Because their prospective increased anti−proliferative efficacy and improved profile, BA derivatives continue be described in scientific literature. The current work was conducted order determine antiproliferative activity, under ...

Ischemic stroke is the leading cause of disability and second death worldwide. However, current therapeutic strategies are scarce limited efficacy. The abundance information available on molecular pathophysiology ischemic has sparked considerable interest in developing new neuroprotective agents that can target different events cascade may be used combination with existing treatments. In this r...

A number of studies have provided evidence that cell death from moderate traumatic spinal cord injury (SCI) is regulated, in part, by apoptosis that involves the caspase family of cysteine proteases. However, little or no information is available about anti-apoptotic mechanisms mediated by the inhibitors of apoptosis (IAP) family of proteins that inhibit cell death pathways. In the present stud...