Introduction: The Serum/Glucose deprivation -induced cell death in cultured PC12 cells represents a useful in vitro model for the study of brain ischemia and neurodegenerative disorders. Nigella sativa L. has been known as a source of antioxidants. To elucidate the neuroprotective actions of N. sativa extract in vitro, we studied the effect of N. sativa extract on cultured PC12 cells under s...

Research on the potential biological activity of red alga Symphyocladia spp. has been limited to latiuscula, which is widely used as a food ingredient in Korea. Here, we examined another species, linearis, found Korea and was reported new species 2013. The aim this study evaluate antioxidant, anti-inflammatory, antibacterial properties 70% ethanol extract S. linearis. Antioxidant activity, eval...

Background: Salviamoorcroftiana Wall. ex Benth. is a herbaceous perennial plant indigenous to the Himalayan mountains and especially common in Kashmir Valley, India. This was selected based on its ethnopharmacological promise dearth of scientific reporting biological activity. study examined anticancer therapeutic potential also sought demonstrate induction apoptosis, autophagy, oxidative stres...

Background: Cloves mean the dried flower bud harvested from a tree of Syzygium aromaticum L. (SA). Objectives: The current study was to identify anti-inflammatory effects SA on lipopolysaccharide (LPS) (0.2 µg/mL)-treated RAW264.7 cells. Materials and Methods: WST-8 cell proliferation assay kit (WST-8) lactate dehydrogenase (LDH) assays were completed observe cytotoxicity SA. Other biochemical ...

Cancer is one of the leading causes deaths worldwide with 18.1 million per year. Although there have been significant advances in anti-cancer therapies, they can often result side effects cardiovascular complications being most severe. Dexrazoxane only currently approved treatment for prevention anthracycline induced cardiotoxicity but are concerns about its use due to development secondary mal...

objective: oxidative stress plays a key role in the pathophysiology of brain ischemia and neurodegenerative disorders.previous studies indicated that viola tricolor and viola odorataare rich sources of antioxidants. this study aimed to determine whether these plants protect neurons against serum/glucose deprivation (sgd)-induced cell death in an in vitro model of ischemia and neurodegeneration....

The endogenous reactive oxygen species ("ROS") formation is associated with many pathologic states such as inflammatory diseases, neurodegenerative diseases, brain and heart ischemic injuries, cancer, and aging. The purpose of this study was to investigate the endogenous sources for "ROS" formation in intact isolated rat hepatocytes, in particular, peroxisomal oxidases, monoamine oxidase, xanth...

Introduction: D-galactose (D-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. In the present study, we selected crocin, the main constituent of Crocus sativus L. (Saffron), against D-gal cytotoxicity in human neuroblastoma SH-SY5Y cells. Materials and Methods:  Cells were pretreated with crocin (25-500 µM) for 24 h and then expos...

Objective: Oxidative stress plays a key role in the pathophysiology of brain ischemia and neurodegenerative disorders.Previous studies indicated that Viola tricolor and Viola odorataare rich sources of antioxidants. This study aimed to determine whether these plants protect neurons against serum/glucose deprivation (SGD)-induced cell death in an in vitro model of ischemia and neurodegeneration....