Computational methods for Target Fishing (TF), also known as Target Prediction or Polypharmacology Prediction, can be used to discover new targets for small-molecule drugs. This may result in repositioning the drug in a new indication or improving our current understanding of its efficacy and side effects. While there is a substantial body of research on TF methods, there is still a need to imp...

In 1984 and 1987, demersal trawl surveys of fish stocks in the western and central Gulf of Alaska were executed by the National Marine Fisheries Service in cooperation with the Fisheries Agency of Japan. Details of the survey design and sampling methods are presented. Fishing power differences resulted from differences among vessels, gears, and trawling procedures. Chartered fishing vessels fro...

Many of us consider ourselves "fishermen." Many fishermen consider themselves good fishermen. A select few of the good fishermen are professional sport-fishermen, those who pursue big fish for a living. All of these fishermen undoubtedly use modern day rods and reels, often with expensive lures and other equipment that are "guaranteed" to produce a good catch .• Not even the best equipment can ...

To interpret long-term trends in age and size at maturation, new statistical methods have recently been devised for estimating probabilistic maturation reaction norms based on data collected for the management of fisheries. Here we apply these methods to three Newfoundland stocks of American plaice (NAFO Divisions 2J3K, 3LNO, 3Ps) and report a clear long-term shift in the maturation reaction no...

To gauge the collateral impacts of fishing we must know where fishing boats operate and how much they fish. Although small-scale fisheries land approximately the same amount of fish for human consumption as industrial fleets globally, methods of estimating their fishing effort are comparatively poor. We present an accessible, spatial method of calculating the effort of small-scale fisheries bas...

Locally sustainable resource extraction activities, at times, transform into ecologically detrimental enterprises. Understanding such transitions is a primary challenge for conservation and management of many ecosystems. In marine systems, over-exploitation of small-scale fisheries creates problems such as reduced biodiversity and lower catches. However, long-term documentation of how governanc...

Globally the majority of commercial fisheries have experienced dramatic declines in stock and catch. Likewise, projections for many subsistence fisheries in the tropics indicate a dramatic decline is looming in the coming decades. In the Pacific Islands coastal fisheries provide basic subsistence needs for millions of people. A decline in fish catch would therefore have profound impacts on the ...

BACKGROUND Falls overboard are a major contributor to commercial fishing fatalities in Alaska. The National Institute for Occupational Safety and Health has repeatedly identified falls overboard as a critical issue in commercial fishing safety. This article describes the problem of falls overboard and discusses possible ways to reduce the risk factors. METHODS Data from the Alaska Occupationa...