semelil is an herbal-based compound which is used for the treatment of chronic wounds, especially diabetic foot ulcers. on the other hand, electrospun nanofibers have many characteristics such as mimicking extracellular matrix structure, efficiency as bacterial barrier, appropriate water vapor transmission rate, and provision of adequate gaseous exchange which make them ideal candidates for wou...

objective(s): nanoparticles (nps) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. the main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. methods: in this study, mesalamine loaded chitosan nanoparticles were pr...

Background: Progress in the field of biology and biochemistry has led to the discovery of numerous bioactive peptides and proteins in the last few decades. Delivery of therapeutic proteins/peptides has received a considerable amount of attention in recent years. Methods: In this study, a two-step desolvation method was used to produce biodegradable hydrophilic gelatin nanoparticles (GNP) as a d...

candesartan cilexetil (cc) is a newer class of angiotensin ii receptor antagonist used for the treatment of hypertension. the solubility of the cc is very poor and its oral bioavailability is only 15%. the controlled-release polar lipid microparticles of cc (formulations f1, f2, f3 and f4) were prepared using variable erodible lipophilic excipients like hydrogenated castor oil, stearic acid, ce...

The aim of this study is to formulate a novel ophthalmic nanosuspension (ONS), an alternative carrier system to traditional colloidal carriers for controlled release (CR) of acyclovir (ACV). In the present study, ONS is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...