Excessive joint surface loadings, either single (acute impact event) or repetitive (cumulative contact stress), can cause the clinical syndrome of osteoarthritis (OA). Despite advances in treatment of injured joints, the risk of OA following joint injuries has not decreased in the last 50 years. Cumulative excessive articular surface contact stress that leads to OA results from post-traumatic j...

introduction: although, the effect of direct intra-articular injection of bone marrow stem cells (bmscs) on the repair of articular cartilage and the effect of elaeagnus angustifolia extract on pain relief in patients with osteoarthritis have been investigated, no studies has been conducted to compare the effects of these two therapeutic methods on the mechanical properties of articular cartila...

Osteoarthritis or degenerative joint disease is a condition characterised by degeneration of articular cartilage often associated with the formation of new bone at joint surfaces on margins. Commonly encountered in dogs, osteoarthritis may have a gradual onset, but may also occur acutely. Osteoarthritis can be a primary disease of joint cartilage, but is more after secondary to abnormal stresse...

Background Joint cartilage degradation is resulted by ensuing chronic inflammation in juvenile idiopathic arthritis (JIA). Since the primary goals of treatment are to prevent joint destruction sensitive methods are needed to evaluate cartilage thickness (CTh). Ultrasonography (US) is a reliable tool in the assessment of joint cartilage in rheumatic disease. Previously, we have shown that CTh, i...

Boundary lubrication of articular cartilage by conformal, molecularly thin films reduces friction and adhesion between asperities at the cartilage-cartilage contact interface when the contact conditions are not conducive to fluid film lubrication. In this study, the nanoscale friction and adhesion properties of articular cartilage from typical load-bearing and non-load-bearing joint regions wer...

Computational models may have the ability to quantify the relationship between hip morphology, cartilage mechanics and osteoarthritis. Most models have assumed the hip joint to be a perfect ball and socket joint and have neglected deformation at the bone-cartilage interface. The objective of this study was to analyze finite element (FE) models of hip cartilage mechanics with varying degrees of ...

OBJECTIVE Joint bleeding, or hemarthrosis, leads in time to severe joint damage. This study was carried out to test the in vitro thresholds of exposure time and concentration that lead to irreversible joint damage, to add to the discussion on the usefulness of aspiration of the joint after a hemorrhage. METHODS Explants of healthy human articular cartilage tissue were cultured in the presence...

INTRODUCTION: Degenerative changes in the structure and composition of articular cartilage in osteoarthritis, such as collagen fibrillation, proteoglycan depletion and increased water fraction, alter the mechanical behavior of cartilage [1, 2]. It has been shown that the collagen fibrils primarily modulate cartilage mechanical response under dynamic and impact loading [3]. This emphasizes the r...