The platelets from 74 patients with acute myocardial infarction or with unstable angina showed decreased prostaglandin E1/12 receptor activity when compared with that of 56 normal volunteers by using [3H]prostaglandin E1 as a probe. In normals, Scatchard analyses showed the presence of one high-affinity-low-capacity (Kd1=9.0±1.2 nM [mean±SD]; n1=120±30 sites/cell) and one low-affinity-high-capa...

abstract the feminist movement in the united states like other countries has tried to establish equality for women. from the first attempts to gain constitutional right for vote, up to the current radical demands, feminists have struggled to make changes in the u.s. party politics and obtain their rights within the parties. one of the important issues in which women played a key role in party p...

The human cytomegalovirus (HCMV) glycoprotein B (gB) (also known as gpUL55) homolog is an important mediator of virus entry and cell-to-cell dissemination of infection. To examine the potential ligand-binding properties of gB, a soluble form of gB (gB-S) was radiolabeled, purified, and tested in cell-binding experiments. Binding of gB-S to human fibroblast cells was found to occur in a dose-dep...

Although coronary artery disease (CAD) is appreciated to be accelerated in patients with chronic spinal cord injury (SCI), the underlying mechanism of CAD in SCI remains obscure. We have recently shown that platelets from subjects with SCI develop resistance to the inhibitory effect of prostacyclin (PGI2) on the platelet stimulation of thrombin generation. The loss of the inhibitory effect was ...

Angiotensin II elicits a receptor-mediated positive inotropic response in cardiac tissue from most mammalian species by activating voltage-sensitive slow Ca2+ channels. In the guinea pig, we confirm there is no in vitro contractile force development in bioassay systems using isolated hearts or left atrial tissue in response to angiotensin peptides. However, 125I-angiotensin II binding sites tha...

Following an internal contamination event, the transport of actinide (An) and lanthanide (Ln) metal ions through the body is facilitated by endogenous ligands such as the human iron-transport protein transferrin (Tf). The recognition of resulting metallo-transferrin complexes (M2Tf) by the cognate transferrin receptor (TfR) is therefore a critical step for cellular uptake of these metal ions. A...

we prove that the class of profinite groups $g$ that have a factorization $g=ab$ with $a$ and $b$ abelian closed subgroups, is closed under taking strict projective limits. this is a generalization of a recent result by k.h.~hofmann and f.g.~russo. as an application we reprove their generalization of iwasawa's structure theorem for quasihamiltonian pro-$p$ groups.