Supply Chain Operations Reference (SCOR) model is developed and maintained by the Supply Chain Council (SCC). The model is a reference model which can be utilized to map benchmark and improve the supply chain operations. SCOR model provides companies with a basic process modeling tool, an extensive benchmark database by defining a set of supply chain metrics. This paper explains the process and...

spurred by intensifying competition in global markets, most companies have been increasingly implementing supply chain management (scm) and information systems (is) practices. as well, globalization policies have created a more intensive competition amongst manufacturers; in additional the priority of supply over demand, market competition and importance of some factor such as quality, accounta...

In the current competitive and dynamic market, customer demands and interests are changing continuously, and hence, risk of disruption in the supply chain is also increasing. To be successful in this scenario, supply chain of a firm should be resilient. Most of the firms realize that with a specific end goal to develop a resilient supply chain, there is a need for assessment of performance. The...

one of the important problems in project management is lack of available resources in proper time at project site that leads to lack of project implementation in due date. this problem may be lead to time delay in sending resources from suppliers and related origins in supply chain to project site. therfore, to better resources managmenet and also the improvement of supply chain condition, the ...

Insulin-like growth factor (IGF)-1 plays crucial roles in growth control and rearrangements of the cytoskeleton. IGF-1 binds to the IGF-1 receptor and thereby induces the autophosphorylation of this receptor at its tyrosine residues. The phosphorylation of the IGF-1 receptor is thought to initiate a cascade of events. Although various signaling molecules have been identified, they appear to int...

The G-protein-mediated Rho guanine nucleotide exchange factor (GEF)-Rho GTPase signaling axis has been implicated in human pathophysiology and is a potential therapeutic target. By virtual screening of chemicals that fit into a surface groove of the DH-PH domain of LARG, a G-protein-regulated Rho GEF involved in RhoA activation, and subsequent validations in biochemical assays, we have identifi...

BACKGROUND RhoA is an important regulator of platelet responses downstream of Gα13 , yet we still know little about its regulation in platelets. Leukemia-associated Rho guanine-nucleotide exchange factor (GEF [LARG]), a RhoA GEF, is highly expressed in platelets and may constitute a major upstream activator of RhoA. To this end, it is important to determine the role of LARG in platelet function...

Diminished insulin sensitivity is a characteristic feature of type 2 diabetes. Inhibition of insulin action, resulting in reduced skeletal muscle glucose uptake, is mediated in part through stimulation of RhoA activity. One regulator of RhoA activity is leukemia-associated Rho guanine nucleotide exchange factor (LARG). The LARG gene maps to a region on chromosome 11q23-24 that shows genetic lin...