All ionizing radiations deposit energy stochastically along their tracks. The resulting distribution of energies deposited in a small target such as the DNA helix leads to a corresponding spectrum in the severity of damage produced. So far, most information about the probable spectra of DNA lesion complexity has come from Monte Carlo studies which endeavour to model the relationship between the...

PURPOSE To study the influence of DNA configuration on the direct damage yield. No indirect effect has been accounted for. METHODS The GEANT4-DNA code was used to simulate the interactions of protons and alpha particles with geometrical models of the A-, B-, and Z-DNA configurations. The direct total, single, and double strand break yields and site-hit probabilities were determined. Certain f...

Providing a high quality and sufficient high current positron beam for the ultra high luminosity B-factory SuperB is a major goal. In this paper a proposition for positrons production and capture scheme based on low energy electrons up to 1 GeV is presented. For this technique, several types of flux concentrator used to capture the positrons are being studied. The following accelerating section...

20 Modelling the radio-induced effects in biological medium requires accurate physics models to 21 describe in detail the main physical interactions induced by all the charged particles present in 22 the irradiated medium (secondary as well as primary ones). These interactions include 23 inelastic events like ionization and excitation processes as well as elastic scattering, the latter 24 being...

Introduction: The choice of optimal radionuclides for radioimmunotherapy depends on several factors, especially the radionuclide and antibody. The dosimetric characteristics of a non-internalizing and an internalizing monoclonal antibody (MAb) labeled with beta emitting radionuclides were investigated. Methods: Using Geant4-DNA Monte Carlo simulation, we ...

The damage induced to a model DNA (dT25) immobilized on a gold surface by the interaction of low-energy (1 eV) electrons was studied by means of microarray technology. High quality single-stranded DNA arrays were hybridized with a dye-marked complementary strand after irradiation with electrons and the normalized fluorescence data were used to quantify the DNA damage. The data clearly show the ...