The development of nerve connections is thought to involve competition among axons for survival promoting factors, or neurotrophins, which are released by the cells that are innervated by the axons. Although the notion of competition is widely used within neurobiology, there is little understanding of the nature of the competitive process and the underlying mechanisms. We present a new theoreti...

Peripheral nerve trauma results in functional loss in the innervated organ, and recovery without surgical intervention is rare. Many surgical techniques can be used for nerve repair. Among these, the tubulization technique can be highlighted: this allows regenerative factors to be introduced into the chamber. Cell therapy and tissue engineering have arisen as an alternative for stimulating and ...

background: bone marrow and umbilical cord stromal cells are multipotential stem cells that have the ability to produce growth factors that play an important role in survival and generation of axons. the goal of this study was to evaluate the effects of the two different mesenchymal stem cells on peripheral nerve regeneration. materials and methods: in this experimental study, a 10 mm segment o...

Background and Objectives:Myocardial infarction (MI) elicits nerve sprouting. However, the time course and spatial distribution of this nerve sprouting and its relationship to the expression of neurotrophic factors is unclear. The aim of this study was to identify the association of nerve sprouting with the expression of neurotrophic factors. Materials and Methods:We induced MI in FVB mice by l...

INTRODUCTION Often, when one experiences trauma or undergoes an invasive surgery, peripheral nerve damage results. Each year 360,000 people in the United States suffer from peripheral nerve injury [1]. Peripheral nerve injury can result in a loss of sensory and or motor function and will often lead to long-term disability in patients [2]. When a peripheral nerve is compressed or severed, the in...

Objective: This article reviews novel restorative therapies for cavernous nerves that may be used to replace resected cavernous nerves at the time of pelvic surgery. Methods: A literature-based presentation (Medline search) on current nerve replacement strategies was conducted with emphasis on neurobiological factors contributing to the restoration of erectile function after cavernous nerve inj...

Clinical background Brain-derived Neurotrophic Factor (BDNF) as a growth factor is part to the family of neurotrophins. It is a central mediator of stress effects to the neuronal plasticity and links stress and affective disorders as well as somatic diseases. The neurotrophic functions of BDNF influence the survival of neurons und thereby important functions as learning, memory, appetite and sl...

Background: Postherpetic neuralgia (PHN) is persistent pain in the affected dermatome that occurs more than three months after eruption of herpes zoster has disappeared. Vitamin D a role Schwann cell regeneration and stimulates release nerve growth factors.