hippocampal neural stem/progenitor cells (hipp-ns/pcs) of the adult mammalian brain are important sources of neuronal and gial cell production. in this study, the main goal is to investigate the plasticity of these cells in neuronal/astroglial differentiations. to this end, the differentiation of the hipp-ns/pcs isolated from 3-month-old wistar rats was investigated in response to the embryonic...

A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with...

beauveria spp. as entomopathogenic fungi have extremely diverse insect host ranges.here, a comparative transcript analysis of a bassiasin i (bsni), a dipeptidyl peptidase (dpp), a cytochrom p450 monooxygenase (cyp52), a mitogen activated protein kinase (mapk), and a neuronal calcium sensor 1 (ncs) in two isolates of beauveria bassiana., with low and high virulence, were carried out. for this, i...

Mesenchymal stem cells (MSCs) have the ability to differentiate into neuronal like cells under appropriate culture condition. In this study, we investigated whether MSCs derived from human peripheral blood (PB-MSCs) can differentiate into neuronal like cells by synergic effect of the growth factors EGF, bFGF and Noggin. For this purpose, the expression of five neuronal markers (Nestin, &beta II...

how to cite this article: schulz a, kohlschütter a. ncl disorders: frequent causes of childhood dementia. iran j child neurol. 2013 winter;7(1):1-8. abstract dementia in children or young adults is most frequently caused by neuronal ceroidlipofuscinoses (ncl), a group of incurable lysosomal storage disorders linked by the accumulation of a characteristic intracellular storage material and progr...

Introduction: It is well established that thyroid hormones are essential for normal development of mammalian brain. Thyroid hormone deficiency during critical period of brain development can exert devastative and irreversible effects on neuronal functions as well as on learning abilities and memory. The aim of the present investigation was to investigate the effects of maternal hypothyroidis...

epilepsy is accompanied with a strong change in neuronal activity not only in excitatory (glutamatergic) and inhibitory (gabaergic) neurotransmission, but also in neuromodulatory agents. dopaminergic system, as an important neuromodulatory system of the brain, has significant effect on neuronal excitability. in addition, this system undergoes many changes in epileptic brain. understanding the e...

ncls, which are some of the most common degenerative disorders, often also cause progressive blindness. the diagnosis is suggested by characteristic inclusions, visible by electron microscope, in a skin or conjunctival biopsy specimen. during the last several years, the biochemical and genetic basis of the ncls has been elucidated. the ncls are characterized by the accumulation of autofluoresce...