The lack of a robust anticancer drug screening system to monitor patients during treatment delays realization of personalized treatment. We demonstrate an efficient approach to evaluate drug response using patient-derived circulating tumor cell (CTC) cultures obtained from liquid biopsy. Custom microfabricated tapered microwells were integrated with microfluidics to allow robust formation of CT...

Gastric cancer imposes a global health burden. Although multimodal therapies have proven to benefit patients with advanced diseases after curative surgery, the prognosis of most advanced cancer patients still needs to be improved. Surgical extirpation is the mainstay of gastric cancer treatment. Indeed, without curative surgery, variations and combinations of chemotherapy and/or radiation canno...

chemical oxidation is one of the most suitable treatment methods for reducing organic pollutants and the number of pathogens remaining in secondary effluents. ozone is the most powerful oxidizing agent commonly used because of it's many advantages over chlorination. in this study the efficiency of ozonation in advanced wastewater treatment of sahebgharanieh plant has been determined. ozone gene...

background: application of potassium ferrate is a chemical oxidation approach used for water and wastewater treatment. the aim of this study is to apply central composite design (ccd) and response surface methodology (rsm) to optimize potassium ferrate consumption in the treatment of wastewater from carpet industries. methods: samples in this experimental study were collected from wastewater, o...

phosphorus is an important nutrient for plant and microorganisms growth, thus has an important role in creating eutrophication of surface waters. the present study has investigated poly aluminum chloride efficiency on orthophosphate removal by coagulation and chemical precipitation process in municipal wastewater in west wastewater treatment plant. this bench scale study was performed on influe...

The advent of personalized medicine has ushered in a new era for cancer therapy with a significant impact on the management of advanced melanoma. Molecular targeted therapies have shown promise in the management of various malignancies, including melanoma, with lower toxicity profiles and better overall survival as compared with conventional therapy. The discovery of BRAF mutations in melanoma ...