Tenofovir, currently marketed as the prodrug tenofovir disoproxil fumarate, is used clinically to treat patients with HIV/AIDS. The oral bioavailability of tenofovir is relatively low, limiting its clinical effectiveness. Encapsulation of tenofovir within modified long-circulating liposomes would deliver this hydrophilic anti-HIV drug to the reticuloendothelial system for better therapeutic eff...

64 Pharmaceutical Technology SEPTEMBER 2005 Don Chambers, PhD,* is the senior director of analytical development for Schering-Plough Research Institute, 2000 Galloping Hill Road, Kenilworth, NJ 07033, tel. 908.740.2318, fax 908.740.2107, donald. [email protected]. Gregg Kelly, PhD, is a senior principal scientist for Pfizer, Inc. (Groton, CT). Giselle Limentani, PhD, is a director of product ...

in this research three-dimensional free vibration analysis of functionally graded circular plate with various boundary conditions is achieved. a semi-analytical method, which makes use of the state space method and the one-dimensional differential quadrature method, is used to obtain the vibration frequencies and dynamic responses of circular plates. numerical results are given to demonstrate t...

In this contribution, the possibility to automatically transfer RPLC methods between different column dimensions and instruments was evaluated using commercial modelling software. The method transfer reliability was tested with loratadine and its 7 related pharmacopeial impurities. In this study, state-of-the-art columns packed with superficially porous particles of 5, 2.6, 1.7 and 1.3μm partic...

Background: Loratadine is a commonly used selective non‐sedating antihistaminic drug. Desloratadine is the active metabolite of loratadine and, in addition, a potential impurity in loratadine bulk powder stated by the United States Pharmacopeia as a related substance of loratadine. Published methods for the determination of both analytes suffer from limited throughput due to the time‐consuming ...

For aseptically filled products, as well for many terminally the sterility test is a mandatory product release test. It is, however, statistically poor at detecting anything other than gross contamination (this limitation has been addressed in number of studies (1)). This relates to few numbers articles tested (2). batches excess 500 containers, pharmacopeia only require that twenty samples are...