Bilateral auricular inflammation with histological changes of relapsing polychondritis was observed in a female patient with primary Sjögren's syndrome. This was accompanied by rapidly progressive renal insufficiency due to diffuse proliferative glomerulonephritis. To our knowledge this is the first well documented case of primary Sjögren's syndrome associated with chondritis and glomerulonephr...

Monoclonal gammopathy of undetermined significance (MGUS) is a common premalignant plasma cell proliferative disorder with a lifelong risk of progression to multiple myeloma. Because myeloma is an incurable malignancy, strategies to delay or prevent progression in high-risk patients are of considerable importance.

Successful Treatment of Rosai-DorfmanDisease With Low-DoseOral Thalidomide Rosai–Dorfman disease (RDD) is a rare idiopathic histiocytic proliferative disorder.1 The skin is the most frequently involved extranodal organ. Nevertheless, primary cutaneous manifestation of RDD (CRDD) without systemic involvement is rare.2 We present herein a case of CRDD showing excellent remission after low-dose or...

Introduction: Proliferation of cancer cells and the potential of metastasis depend on the activity of different biomarkers such as proliferative ones. Proliferative biomarkers including ki-67, cyclin E1, cyclin D1, p27, and p21 were analyzed through immunohistochemistry (IHC) in previous studies. Methods: The current study aimed at investigating the utilizing role of RT-PCR in studying prolife...

Idiopathic retroperitoneal fibrosis (IRPF) is a rare disease characterized by a retroperitoneal inflammatory proliferative fibrosing process. Hashimoto's thyroiditis is the most common inflammatory condition of the thyroid gland; and is a frequently-occurring autoimmune disorder manifesting predominantly in middle-aged women. We report a rare association of IRPF with Hashimoto's thyroiditis in ...

INTRODUCTION Langerhans' cell histiocytosis is a proliferative histiocytic disorder of unknown cause originating from dendritic cells. CASE PRESENTATION The authors report a case of Langerhans' cell histiocytosis in a 48-year-old man with multisystemic disease presentation, including liver involvement. CONCLUSION Hepatic involvement is an uncommon feature in this rare disease and there is n...

Chronic lymphocytic leukemia (CLL) is a B cell disorder in which major T cell proliferative defects are present. We investigated the nature of this deficit by studying several parameters known to be crucial in normal T cell proliferative response to mitogen. Purified peripheral blood T cells from B-CLL patients were analyzed for the presence of T3 antigen. We observed that CLL T cells have a di...

In 40 patients with a histological diagnosis of proliferative glomerulonephritis the deposition of immunoglobulins, complement (C(3)), and fibrin/fibrinogen has been assessed by immunofluorescence and electron microscopy. The results of such examinations have been correlated with the outcome of the illness. In minor or resolving disease there is usually minor functional impairment, a good respo...

propose: to evaluate patients with renal transplantation for abnormal ocular findings and to determine the association of these findings with pretreatment dialysis duration, immunosuppressive regimen and underlying disease causing renal failure. methods: this cross-sectional study was performed on 150 patients who had undergone kidney transplantation for at least three months and with serum cre...

We report two cases of angiofollicular lymph node hyperplasia of the hyaline-vascular type. The patients were atypical in having systemic complications, which are much more commonly seen in the plasma cell variant of this disorder. In each case, the diagnosis was established some years after the initial presentation. Both patients presented with unusual systemic manifestations. The exact mechan...