Astrocytes extend highly branched processes that form functionally isolated microdomains, facilitating local homeostasis by redistributing ions, removing neurotransmitters, and releasing factors to influence blood flow and neuronal activity. Microdomains exhibit spontaneous increases in calcium (Ca2+), but the mechanisms and functional significance of this localized signaling are unknown. By de...

The effect of event-dependent sampling of processes consisting of recurrent events is investigated when analyzing whether the risk of recurrence increases with event count. We study the situation where processes are selected for study if an event occurs in a certain selection interval. Motivation comes from psychiatric epidemiology where repeated hospital admissions are studied for patients wit...

26 27 Rotifer resting eggs often have to endure harsh environmental conditions during the diapause phase. 28 They are stimulated by light to hatch. In order to study the hatching mechanism, we observed 29 resting eggs and measured their transcriptional expression under different light exposure periods 30 (total darkness, and after 30 min, and 4h light). By using differential-display reverse tra...

Meyer (1971) showed that any point process whose compensator has continuous paths that increase to ∞ can be time-scaled to a standard Poisson process. In this article we consider the converse to this result. We construct a time change with continuous paths increasing to ∞ that transforms a standard Poisson process into a general point process with totally inaccessible arrivals and compensator g...

Currently, multiple decrement theory is based on the assumption that competing causes of decrement are stochastically independent, even though this assumption is usually not true in reality. This paper presents wellknown results in the theory of dependent competing risks that are fundamental in extending multiple decrement theory towards a dependent decrement theory. First, the state of the art...