Human being is creature that blessed with a knowledge and curiosity. The human recognized by body varies genotypically but somewhat similar phenotypically. gaining of the reflected in form speaking ,and this mainly function tongue teeth. Gums are structure surrounds teeth dental terminology, gums called as gingiva. These utmost importance both from oral health point view systemic view. In short...

Clinics and pathology Disease De novo ANLL; (one case of blast crisis CML). Phenotype / cell stem origin Mainly M2 or M4, but also M1, M5a, M5b, or M7 ANLL; may be preceded by MDS. Epidemiology About 30 reported cases, mainly found in young adults; children cases are described; median age is about 30 yrs; balanced sex ratio. Clinics Blood data: anemia, thrombocytopenia, mild hyperleucocytosis; ...

The breakpoint on chromosome 20 is not constant; 20qis frequently associated with other cytogenetic abnormalities as del(5q), trisomy 8, trisomy 21, deletions or translocations involving the long arm of chromosome 13; a newly described translocation t(11;20)(p15;q11) resulting in a NUP98TOP1 fusion gene was described in therapy-related myelodysplastic syndrome (RAEB); t(11;20)(p15;q11) is a rar...

Although the underlying mechanism for these chromosomal alterations is unclear, it is possible that chromosomes with large constitutive heterochromatin bands such as chromosome 1 may be at risk of centromeric instability and be predisposed to centromeric fusion with other chromosomes. This possibility is supported by observations that unbalanced chromosome rearrangements frequently involve the ...

Disease Myelodysplastic syndrome (21 cases), Acute Myeloid Leukemia (5 cases), Chronic Myelomonocytic Leukemia (1 case). Phenotype/cell stem origin Thrombopenia (90%) with anemia (60%). Dysplastic changes in bone marrow: dyserythropoeisis associated with dysgranulopoieisis and/or dysmegakaryocytopoeisis. Epidemiology The frequency of ider(20q) is estimated at 0.49% in myelodysplastic syndrome a...

Genes involved and proteins TAL1 Location 1p32 DNA/RNA Complex alternate splicing. Protein Contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation. Yet unknown gene Location 5q31 Result of the chromosomal anomaly Hybrid gene Description Breakpoint on TAL1 was found 10 kb upstream the gene, as was found in the ...

This study assessed fluoride (F) and sodium trimetaphosphate (TMP) release into artificial saliva from varnishes containing 0%, 2.5%, and 5% NaF, supplemented or not with 5% TMP. The varnishes were applied on polyester sheets (n = 8/group), and F and TMP released into artificial saliva were measured for up to 24 hours. The amount of F and TMP released were directly related to NaF and TMP concen...

Few studies focused on B-PLL; the use of B-cell mitogens might increase the detection rate of cytogenetic changes; the most frequent aberrations involve chromosomes 14, 6 and 1; 14q+ changes are the most commonly observed and are often the consequence of a translocation t(11;14)(q13;q32); structural abnormalities of chromosome 6 are primary or secondary; deletion 6q, as well as translocation t(...