typhoid fever is one of the most important infectious diseases transmitted by contaminated food and water. this study aimed at epidemiological features of disease during the last five decades, over the period from 1962-2011.a retrospective cross-sectional study was conducted using typhoid fever national surveillance data.the highest incidence of typhoid fever was registered in 1965 with 133.4 /...

Background and Objective: The diagnosis of typhoid fever in children is a challenge due to the non-specific clinical picture. The current role of the Widal test for diagnosis in developing countries has not been clear. Materials and Methods: Charts were reviewed on all children ≤ 15 years of age discharg...

BACKGROUND Typhoid fever remains an important cause of illness and death in the developing world. Uncertainties about the protective effect of Vi polysaccharide vaccine in children under the age of 5 years and about the vaccine's effect under programmatic conditions have inhibited its use in developing countries. METHODS We conducted a phase 4 effectiveness trial in which slum-dwelling reside...

BACKGROUND Afghanistan's public health system was neglected during decades of military and civil conflict, and trends in infectious disease occurrence remain poorly characterized. This study examines cyclical and long-term trends of six vaccine-preventable diseases: pneumonia, diarrhea, meningitis, typhoid, measles, and acute viral hepatitis. METHODS Using weekly data collected between 2009 a...

the aim of this study was to characterize the effect of typhoid fever on pharmacokinetic parameters of levofloxacin (lf) and compare the pharmacokinetic parameters of the said antibiotic in healthy human volunteers and patients with typhoid fever. total of 12 subjects were divided into two groups “a” (healthy volunteers) and “b” (typhoid patients). single oral dose of lf 500 mg was given and 5 ...

typhoid fever is an endemic disease in iran and other developing countries. this disease has gradually become resistant to the first line of drugs, and because of this resistancy we have studied a new alternative drug (cefixime) on typhoid fever patients and compared it's effectiveness with chloramphenicol. for this purpose, by a randomized clinical trial in emam khomeini hospital between ...

To determine the changing spectrum of typhoid fever, a study was conducted on 240 cases of typhoid fever, admitted over a period of 4 years. The classical ‘Stepladder fever’ and ‘relative bradycardia’ were less commonly seen. Presentation as hepatitis, psychosis, meningism, myocarditis, polyneuropathy and diarrhoea were encountered in a small number of patients. Reversible proximal myopathy occ...

BACKGROUND Typhoid fever is a systemic infection caused by the bacterium Salmonella enterica serovar Typhi. Age, sex, prolonged duration of illness, and infection with an antimicrobial resistant organism have been proposed risk factors for the development of severe disease or fatality in typhoid fever. METHODS We analysed clinical data from 581 patients consecutively admitted with culture con...