BACKGROUND Wilson disease (WD) is an autosomal recessive disorder caused by defects in the ATPase, Cu(2+) transporting, beta-polypeptide gene (ATP7B) resulting in accumulation of copper in liver and brain. WD can be thwarted if detected at a presymptomatic stage, but occasional recombination during carrier detection with dinucleotide repeat markers flanking the WD locus may lead to faulty diagn...

OBJECTIVE To describe work status and factors associated with work disability (WD) in patients with SSc. METHODS A systematic search strategy in various electronic databases from 1990 to 2011 was performed. All clinical studies concerning SSc patients containing quantitative information on work status and/or factors associated with WD were selected. Extracted were study characteristics, data ...

BACKGROUND We examined if a purported anti-inflammatory supplement (AF) abrogated Western-diet (WD)-induced liver pathology in rats. AF contained: 1) protein concentrates from bovine colostrum and avian egg yolk; 2) herbal adaptogens and antioxidants; and 3) acetyl-L-carnitine. METHODS Nine month-old male Brown Norway rats were allowed ad libitum access to WD for 41-43 days and randomly assig...

We model recent experimental wavelength dependent Three Pulse Photon Echo Peak Shift ͑WD-3PEPS͒ and Transient Grating ͑WD-TG͒ signals considering both solvation dynamics and vibrational contributions. We present numerical simulations of WD-3PEPS and WD-TG signals of two probe molecules: Nile Blue and

BACKGROUND & OBJECTIVES Wilson disease (WD) is an autosomal recessive disorder caused by defects in ATP7B gene located in chromosome 13q14, and manifested as hepatolenticular degeneration as a result of accumulation of copper. No information on the mutation in the ATP7B gene and haplotypes using linked markers is available for WD patients in India. Hence, the present study was undertaken to ide...

PURPOSE To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD). METHODS Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR...

we report a patient diagnosed with whipple's disease (wd) who presented only with neurological symptoms. neuroimaging (mri) showed lesions with marked mass effect similar to infiltrative tumors, which were hypersignal on long tr and hyposignal on short tr images, located in several areas of the brain. in serial controls, lesions resolved with gliosis and atrophic changes as well as migration of...

Withdrawal (WD) anxiety is a significant factor contributing to continued alcohol abuse in alcoholics. This anxiety is extensive, long-lasting, and develops well after the obvious physical symptoms of acute WD. The neurobiological mechanisms underlying this prolonged WD-induced anxiety are not well understood. The basolateral amygdala (BLA) is a major emotional center in the brain and regulates...

We explain the physics of compressional heating of the deep interior of an accreting white dwarf (WD) at accretion rates low enough so that the accumulated hydrogen burns unstably and initiates a classical nova (CN). In this limit, the WD core temperature (Tc) reaches an equilibrium value (Tc,eq) after accreting an amount of mass much less than the WD’s mass. Once this equilibrium is reached, t...