Clinical reports indicate that cardiotoxicity due to donepezil can occur after coadministration with cilostazol. We speculated that the concentration of donepezil in heart tissuemight be increased as a result of interactionwith cilostazol at efflux transporters suchasP-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2), which are expressed inmany tissues including the...

The effect of bromocriptine, a dopamine agonist, administered in the form of bromocriptine alginate nanocomposite (BANC) was studied on Parkinson’s disease (PD) model flies. The synthesized BANCwas subject to characterization and, at a final concentration of 0.5, 1.0 and 1.5 μM, was mixed in diet. The PD flies were allowed to feed on it for 24 days. A significant dose-dependent delay in the los...

For many years, the conventional wisdom in the field of mental health has been that severe mental illnesses, particularly schizophrenia, inevitably result in progressive deterioration. Professional practice has then understandably focused on managing psychopathology and its symptoms. Research efforts in the 1960s, 1970s and 1980s documented the heterogeneity of outcomes, particularly for indivi...

We study monodromy action on abelian varieties satisfying certain bad reduction conditions. These conditions allow us to get some control over the Galois image. As a consequence we verify the Mumford–Tate conjecture for such abelian varieties.