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  Background and Objectives: Serotonergic system has a role in procedure of morphine dependence and withdrawal signs incidence. On the other hand it has been shown that antidepressants may reduce the abuse susceptibility of opioids . So, the aim of this study was to investigate the effect of citalopram as a selective serotonin reuptake inhibitor (SSRIs) antidepressant on morphine withdrawal sig...

The role of serotonergic systems in learning processes is even more controversial: For example serotonergic lesion have been reported to facilitate, impair, or have no effect on performance in various learning tasks. There are several possible explanations for these discrepancies; different importance of  confounding activation of different learning processes, different importance of con...

زمینه:بیماری آلزایمر با کاهش تدریجی توانایی های ذهنی و اختلالات رفتاری مشخص می گردد و شایع ترین نوع زوال عقلی می باشد. این مطالعه مروری، درمان های کنونی برای نقایص شناختی و اختلالات رفتاری و روش های درمانی جدید در درمان این بیماری بررسی خواهد شد. مواد و روش‌ها:در این مطالعه مروری کار آزمایی های بالینی شاهدی موردی و همچنین مطالعات باز که دارای اعتبار کافی بودند بررسی شدند. از کلید واژه های آلزا...

  Background and Objectives: Depression is a serious mental disorder which many people suffer from it. Hippocampus is one part of the brain whose destruction is regarded as important in depression. The purpose of this study was to investigate the structure of the neurons included in hippocampus of depressed rats which were treated with saffron aqueous extract and citalopram.   Material and Meth...

Âcute mandibular dystonia is a dystonic reaction that usually occurs due to antipsychotic drugs and rarely after selective serotonin reuptake inhibitors (SSRÏs). Ïn this study we reported a case of acute mandibular dystonia following administration of citalopram.

Background: The role of citalopram (a tricyclic antidepressant of SSRI group) on ouabain-induced arrhythmia in guinea pig was well established. Materials and methods: Thirty-two guinea pigs were randomly assigned in any of the four groups citalopram, ouabain, citalopram+ouabain, and control. The Na, K, and Ca concentrations were measured using atomic absorption technique. Results: Citalopram ...

Background: Different treatment used for resolving menopausal problems. Some studies assayed effectiveness of citalopram but it had some side effects and other studies about medicinal plants in Iran, including Melissa (combination of officinalis and foeniculum vulgare) showed improvement insomnia and anxiety. This study decided to assay effectiveness of this drug and comparison with placebo and...

Background and purpose: Prevalence of depression in patients with acute coronary syndrome (ACS) is reported to be 10-40%. Post-ACS depression is associated with higher mortality and morbidity in patients, therefore, it requires more attention. Materials and methods: In a clinical trial (conducted in Babol University of Medical Sciences, 2015-2016), 47 hospitalized patients with ACS diagnosis w...

از سال 1988 که استفاده از فلوکستین در درمان افسردگی توسط FDA تأیید شد، داروهای مهارکننده‌ی اختصاصی بازجذب سروتونین، به‌عنوان رایج‌ترین داروهای درمان اضطراب و افسردگی به شمار می‌آیند. از 1990 مصرف این داروها علاوه بر افسردگی، در اختلال وسواسی جبری، اختلال اضطرابی منتشر و سایر اختلالات نیز مورد تأیید قرار گرفت. ورود این داروها به چرخه‌ی درمان اختلالات روان‌پزشکی، به دلیل عوارض کم‌تر و قابل تحمل‌ت...