BACKGROUND AND PURPOSE it is hypothesized that tissue plasminogen activator rescues brain tissue by improving perfusion. In this study, we aimed to examine acute regional perfusion changes and how they influence infarction and clinical outcome. METHODS three sequential MR scans were performed in 15 tissue plasminogen activator-treated patients within 3.5 (tp1), at 6 hours (tp2), and at 1 mont...

We previously identified a peptide aptamer (named R5G42) via functional selection for its capacity to slow cell proliferation. A yeast two-hybrid screen of human cDNA libraries, using R5G42 as "bait," allowed the identification of two binding proteins with very different functions: calcineurin A (CnA) (PP2B/PPP3CA), a protein phosphatase well characterized for its role in the immune response, a...

The structure of chromatin undergoes extensive alteration during mammalian spermatogenesis. Several testis specific histone subtypes are synthesised and replace their somatic counterparts during pre-meiotic, meiotic and post-meiotic stages of germ cell differentiation. Early work from our laboratory showed that pachytene spermatocyte nuclei as well as nucleosome core particle are more accessibl...

PURPOSE To determine whether in patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue lymphoma (MALT), delayed-time-point 2-F-fluoro-2-deoxy-d-glucose-positron emission tomography (F-FDG-PET) performs better than standard-time-point F-FDG-PET. MATERIALS AND METHODS Patients with untreated histologically verified MALT lymphoma, who were undergoing pret...

We performed sensitive polymerase chain reaction–based minimal residual disease (MRD) analyses on bone marrow samples at 9 follow-up time points in 71 children with T-lineage acute lymphoblastic leukemia (T-ALL) and compared the results with the precursor B-lineage ALL (B-ALL) results (n 210) of our previous study. At the first 5 follow-up time points, the frequency of MRD-positive patients and...

The aim of this study was to investigate the effect of triptolide on ATP‑binding cassette transporter A1 (ABCA1) expression in lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in rats. Thirty male Sprague Dawley rats weighing 200‑250 g were randomly divided into six groups: Normal (N, n=5), Control (C, n=5), LPS (L, n=5), Triptolide 25 µg (TP1, n=5), Triptolide 50 µg (TP2, n=5) and Trip...

Figure 2. (a) ADC (unit 1×10 mm/s) changes in the presence and absence of reperfusion; (b)histogram of tp2 ADC in the reperfused ROI that did (infarct) and did not (noninfarct) go on infarction. The two vertical lines show ADC abnormal threshold (left) and normal mean (right). Figure 1. Representative ADC, MTT at tp1 and tp2 and FLAIR at tp3 from two patients. The range of the colorbar is from ...

In this paper, one studies the famous well-known and challenging Tweety Penguin Triangle Problem (TPTP or TP2) pointed out by Judea Pearl in one of his books. We first present the solution of the TP2 based on the fallacious Bayesian reasoning and prove that reasoning cannot be used to conclude on the ability of the penguin-bird Tweety to fly or not to fly. Then we present in details the counter...