The suicide inhibitory mechanism of serine protease inhibitors of the serpin superfamily depends heavily on their structural flexibility, which is controlled in large part by the breach and shutter regions of the central Abeta-sheet. We examined codon usage by the highly conserved residues, Ser-53 and Ser-56, of the shutter region and found a TCN-AGY usage dichotomy for Ser-56 that remarkably i...

Theoretical analysis and Computer simulations have proven to be cost-effective and powerful tools in scientific studies of materials, particularly at nano-scale where synthesis of nano-structures, interpretation of their observed character and exploration of new structures are not always straight forward. We present here fundamental principles of techniques used today for computational simulati...

Residue 225 in serine proteases is typically Pro or Tyr and specifies an important and unanticipated functional aspect of this class of enzymes. Proteases with Y225, like thrombin, are involved in highly specialized functions like blood coagulation and complement that are exclusively found in vertebrates. In these proteases, the catalytic activity is enhanced allosterically by Na+ binding. Prot...

Jonah Lehrer könyve a döntéshozatali folyamatokat vizsgálja és mutatja be kifejezetten szemléletes gyakorlati példákon keresztül. Az írás alapkérdéseit szerz? így fogalmazza meg: „Hogyan hoz döntéseket az emberi elme? És hogyan lehet ezeken döntéseken javítani?” (Lehrer, 2012). A mechanizmusok meghatározzák mindennapjainkat. Igaz ez munkahelyi életünkre csakúgy, mint magánéletünkre. tudomány ké...