one of the most important extensions of the capacitated vehicle routing problem (cvrp) is the vehicle routing problem with simultaneous pickup and delivery (vrpspd) where customers require simultaneous delivery and pick-up service. in this paper, we propose an effective ant colony optimization (eaco) which includes insert, swap and 2-opt moves for solving vrpspd that is different with common an...

The location-routing problem is the most significant and yet new research field in location problems that considers simultaneously vehicle routing problem features with original one for achieving high-quality integrated distribution systems in beside of the global optimum. Simultaneous pickup and delivery based on time windows are the two main characteristics of logistic management that have be...

Location-Routing Problem (LRP) emerges as one of the hybrid optimization problems in distribution networks in which, total cost of the system would be reduced significantly by simultaneous optimization of locating a set of facilities among candidate locations and routing vehicles. In this paper, a mixed integer linear programming model is presented for a two-echelon location-routing problem wit...

BACKGROUND AND PURPOSE Few acute stroke patients are treated with alteplase, partly because of significant prehospital delays after symptom onset. The aim of this study was to determine among ambulance-transported stroke patients factors associated with stroke recognition and factors associated with a call for ambulance assistance within 1 hour from symptom onset. METHODS For 6 months in 2004...