Investigation into antimalaria activity of various fractions of Morinda lucida leaf extract and Alstonia boonei stem bark was conducted using standard techniques. The present study confirms the antimalarial activity of Morinda lucida and Alstonia boonei. Morinda lucida exhibited MIC of 0.6mg/ml and Alstonia boonei MIC 0.2mg/ml. The anti plasmodia activity of both plants were found to reside maj...

Sen Gupta (1942), summing up the current opinion of different workers on the subject, thinks that the symptoms of idiosyncrasy in the course of a malaria infestation are due to hypersensitiveness to the malaria parasites or products of the destruction of the red blood cells ; that would explain why the symptoms v of idiosyncrasy usually appeared at the onset of the malarial paroxysms and never,...

The Schools Malaria Project (http://emalaria.soton.ac.uk/) brings together school students with university researchers in the hunt for a new antimalaria drug. Malaria kills a child every thirty seconds, and 40% of the world’s population lives in countries where the disease is endemic. Resistance to existing drugs is increasing and there is a growing need for new compounds. This challenge is bei...

Malaria parasite strains have emerged to tolerate the therapeutic effects of the prophylactics and drugs presently available. This resistance now poses a serious challenge to researchers in the bid to overcome malaria parasitic infection. Recent studies have shown that FK520 and its analogs inhibit malaria parasites growth by binding to FK506 binding proteins (FKBPs) of the parasites. Structure...