نتایج جستجو برای: archival breast cancer tissues
تعداد نتایج: 1151518 فیلتر نتایج به سال:
although breast tuberculosis still remains rare, but in endemic countries should be in differential diagnosis of breast cancer and abscess. imaging modalities cannot distinguish between cancer and tuberculosis. acid fast bacilli stain; culture and pcr are helpful diagnostic methods but unfortunately are not very sensitive. negative results do not rule out this diagnosis, so it seems definite di...
PURPOSE The present study was aimed at clarifying the expression of astrocyte elevated gene-1 (AEG-1), one of the target genes of oncogenic Ha-ras, in breast cancer and its correlation with clinicopathologic features, including the survival of patients with breast cancer. EXPERIMENTAL DESIGN The expression of AEG-1 in normal breast epithelial cells, breast cancer cell lines, and in four cases...
Background and objectives: Deregulation in the expression of microRNAs is involved in the pathogenesis of various malignancies. Impaired microRNAs processing pathway is one possible mechanism for global deregulation of the miRNAs. Exportin 5 (XPO5) is a key member of this pathway that links nuclear and cytoplasmic steps of miRNAs biogenesis together. XPO5 deregulation has been reported in ...
Signal Transducer and Activation of Transcription factors (STAT3 and STAT5) play important roles in breast epithelial cell differentiation, proliferation, and apoptosis. They have been investigated extensively in established breast cancer, but their activation status in precancerous lesions has not been reported. Formalin-fixed, paraffin-embedded archival tissues from 59 cases of atypical ducta...
Background: Researchers are always trying to find specific markers which express specifically in cancer. These specific markers help to diagnose and treat cancer without affecting normal tissues. Cancer-testis antigens are among the new promising biomarkers, especially for targeted therapy. These markers are specially expressed in testis. Various studies have been reported individual expression...
background: amplification of her2 is seen in 20-30% of breast cancer cases. measurement of her2 gene amplification appears to be of vital importance in planning the treatment schedule for patients with breast carcinoma. the aim of our study was to evaluate her2 amplification status in malignant and benign breast tumors by differential pcr (dpcr). materials and methods: the genomic dna was extra...
Background and purpose: Matrix metalloproteinase are a family of proteolytic enzymes that have specific functions in digestion of cells cohesive extra cellular matrix and also, increasing metastasis behavior of acute human tumors. It has been reported that MMPs in two forms, namely proenzyme and active enzyme in biological samples. It is distinguished that among this family, (MMP-9) Matrix Me...
Metastasis to the periocular soft tissue of the orbit is a rare manifestation of metastatic cancer. Infiltrating lobular breast cancer (ILBC) is a special breast cancer subtype, which accounts for 10-15% of all mammary carcinomas and for ~1% of all malignancies. Here, we report on a high frequency of lobular breast cancer in patients with orbital metastases identified in an original series of m...
PURPOSE More than 20 million archival tissue samples are stored annually in the United States as formalin-fixed, paraffin-embedded (FFPE) blocks, but RNA degradation during fixation and storage has prevented their use for transcriptional profiling. New and highly sensitive assays for whole-transcriptome microarray analysis of FFPE tissues are now available, but resulting data include noise and ...
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