The interaction of human serum albumin with Ethyl 2-[2-(dimethylamino)-4-(4-nitrophenyl)- 1,3-thiazole-5-yl]-2-oxoacetate was investigated by using isothermal titration UV-visible spectrophotometry in tris-buffer, pH 7.4. According to these results, it was found that there are a set of 4 binding sites for this ligand on HSA with positive cooperativity in the binding process. This thiazole deriv...

A definition is formulated of the scattering matrix for a closed physical system with bound states which makes use throughout only of the assumed observable p~operties of the system. A direct product space, X, is defined in which the ingredient factor space comprises the steady states-vacuum, oneparticle, and bound states-of the physical system. It is argued that the boundary conditions for a s...

if we think of the graph as modeling a network, the vulnerability measure the resistance of the network to disruption of operation after the failure of certain stations or communication links. many graph theoretical parameters have been used to describe the vulnerability of communication networks, including connectivity, integrity, toughness, binding number and tenacity.in this paper we discuss...

Understanding the interactions of proteins with their ligands requires knowledge of molecular properties, such as binding site affinities and the effects that binding at one site exerts on binding at other sites (cooperativity). These properties cannot be measured directly and are usually estimated by fitting binding data with models that contain these quantities as parameters. In this study, w...

background dermatophytosis is a cutaneous fungal infection with a worldwide occurrence. in dermatophyte infections, the release of keratinocyte cytokines, in the presence of dermatophyte antigens, causes an acute phase response; subsequently, the acute-phase proteins are produced by hepatocytes. mannose–binding lectin (mbl), an acute-phase protein, also acts as a kind of pattern recognition rec...

Abstract We employ machine learning to derive tight-binding parametrizations for the electronic structure of defects. test several methods that map atomic and a defect onto sparse parameterization. Since Multi-layer perceptrons (i.e., feed-forward neural networks) perform best we adopt them our further investigations. demonstrate accuracy parameterizations range important properties such as ban...

UV-visible and Fluorescence spectroscopic methods were employed to study the interaction of human serum albumin (HSA) with Valacyclovir Hydrochloride. Additionally, molecular dynamics and molecular docking simulations were used to visualize and specify the binding site of Valacyclovir Hydrochloride. The Stern-Volmer and van't Hoff equations along with spectroscopic observations, were used to de...

introduction: the consumption of dietary fiber plays an important role in the prevention of illnesses such as diabetes type 2, hypercholesterolemia. dietary fibers are not only desirable for their nutritional properties but also for their functional and technological properties. this study was undertaken to investigate the possibility of alkaline hydrolysis to remove fiber from rice bran. mater...