most of the biological phenomena are influenced by intermolecular recognition and interaction. thus, understanding the thermodynamics of biomacromolecule ligand interaction is a very interesting area in biochemistry and biotechnology. one of the most powerful techniques to obtain precise information about the energetics of (bio) molecules binding to other biological macromolecules is isothermal...

Objective: To assess and compare the pharmacokinetics and bioavailability of methylergometrine (ME) in men and non-pregnant women. Design: A cross-over design was used for an oral dose of 0,125 mg and an intravenous dose of 0.200 mg of ME in 6 men and 6 non-pregnant women (parallel-design in gender). Results: After intravenous administration, the pharmacokinetic profile of ME was described with...

This study aimed to investigate a food effect on the bio-availability of modified-release (MR) trimetazidine tablets in 36 healthy volunteers. Trimetazidine, an anti-ischemic drug, protects the myocardial cell from the harmful effects of ischemia. The authors investigated the effect of being under a fasting or fed state at the time of drug intake on the bioavailability of trimetazidine 35-mg MR...

Implementation of optogenetic techniques is a recent addition to the neuroscientists' preclinical research arsenal, helping to expose the intricate connectivity of the brain and allowing for on-demand direct modulation of specific neural pathways. Developing an optogenetic system requires thorough investigation of the optogenetic technique and of previously fabricated devices, which this review...

We are motivated by the longstanding challenge of determining the structure of a language from its superficial features. Principles & Parameters theory (Chomsky, 1981) hypothesized that human babies are born with an evolutionarily tuned system that is specifically adapted to natural language, which can predict typological properties (“parameters”) by spotting telltale configurations in purely l...