Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...

bladder cancer is the fifth most common cancer with significant morbidity and mortality. recently, numerous studies demonstrated that micrornas are emerging as diagnostic biomarkers for bladder cancer. specific mirna profiles have been identified for several samples from patients with bladder cancer. micrornas are noncoding rna molecules of approximately 23 nucleotides that play important roles...

Bladder cancer (BC) ranks the second most common genitourinary tract malignant tumor with high mortality and 70% recurrence rate worldwide. MiRNAs expression has noticeable role in bladder tumorigenesis. The purpose of this study was to assess miR-200c, miR-30b and miR-141 in tissue samples of patients with BC and healthy adjacent tissue samples and their association with muscle invasion, grade...

RUNX3 is inactivated at high frequency in many tumors. However, in most cases, inactivation is caused by silencing of the gene due to promoter hypermethylation. Because epigenetic silencing is known to affect many major tumor suppressor genes in cancer cells, it is not clear whether RUNX3 is primarily responsible for the induction of carcinogenesis in these cases, except for the gastric cancer ...

Background: Bladder cancer is a common type of urinary system in the world with high morbidity and mortality if not managed optimally. Currently, partial cystectomy has experienced resurgence as less morbid oncologically effective treatment. Here, we appropriately diagnosed surgically treated 5 patients without frozen section reviewed outcome this procedure. Case presentation: The diagnosis was...

background: most patients with superficial bladder cancer whoundergo transurethral resection of bladder tumor show recurrenceof the disease. so far, there have been numerous studies on waysto decrease bladder cancer recurrence, including the intake ofvitamins and antioxidants. the goal of this study was to investigatethe effect of vitamin e on the recurrence of non‑invasive bladdercancer.method...

We aimed to present a case report of bladder metastasis in patient with renal cell cancer (RCC), which is very rare condition. Bladder metastases from RCC are extremely rare. can metastasize through hematogenous, lymphogenous and urinary tract spread. How metastasizes the not clearly understood. Dissemination or also called antegrade pathway another form ureter bladder. This theory was original...

Objective(s):We investigated the relationship between the expression of tumor necrosis factor-inducible gene 6 (TSG-6) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC.   Materials and Methods: Expression of TSG-6 and uroplakin III was det...