The effect of orally supplemented coenzyme Q10 (CoQ10) on plasma CoQ10 concentration and aerobic capacity in endurance athletes was evaluated. Eighteen volunteer male road cyclists and triathletes, 8 in a CoQ10 supplementation group (QG) and 10 in a placebo group (PG), successfully completed the experimental protocol. Subjects were evaluated during and following graded cycling exercise tests, w...

Background: Oxidative stress (OS) contributes to the development of some disorders, including malignancies, metabolic diseases, Alzheimer's disease, and Parkinson's disease. Objectives: The effects coenzyme Q10 (CoQ10) supplementation on OS parameters have been assessed through an updated systematic review meta-analysis. Methods: Scopus, PubMed, Cochrane Library, EMBASE, Web Sciences were used ...

Statins are currently the most effective drugs in reducing low-density lipoprotein cholesterol (LDL-C). With their mechanism of action, by inhibiting 3-hydroxy-3 methylglutharyl coenzyme A reductase, statins decrease cholesterol production. The same biosynthetic pathway is shared by ubiquinone or coenzyme Q10. Statins block production of dekaprenyl-4-benzoate, a precursor of coenzyme Q10 (CoQ10...

In previous works we demonstrated an inverse correlation between plasma Coenzyme Q10 (CoQ10) and thyroid hormones; in fact, CoQ10 levels in hyperthyroid patients were found among the lowest detected in human diseases. On the contrary, CoQ10 is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disord...

Background: Fatigue is a common side effect in cancer patients undergoing radiation therapy (RT). Radiation-induced fatigue affects the quality of life, but there is no definitive treatment option. In this study, the weight-loaded forced swim test was performed to assess the effect of coenzyme Q10 (CoQ10) on radiation-induced fatigue. Materials and Methods: A total of 60 rats were divided rando...

In recent years, there has been a growing interest in using herbal and nutritional supplements for the prevention of prostate cancer. Products such as selenium, vitamin E, lycopene and more recently Coenzyme-Q10 (CoQ10) have all been implicated as possibly conferring protection against the disease. The main purpose of this study is to determine if CoQ10 has any physiologic effects in human pros...

Coenzyme Q10 (CoQ10) is synthesized in almost all human tissues and presumably involved in age-related alterations and diseases. Here, we examined the impact of aging and sex on the serum CoQ10 status in 860 European adults ranging in age from 18 to 82 years. We identified an inverse U-shaped relationship between CoQ10 concentration and age. Women showed lower cholesterol-adjusted CoQ10 levels ...

PURPOSE To determine the concentration of coenzyme Q10 (CoQ10) in the human retina. METHODS Eye tissues were lyophilized and exhaustively extracted with heptane. The extracts were analyzed for CoQ10 by high-performance liquid chromatography (HPLC). RESULTS The average concentration of CoQ10 in the retina was 42+/-11 nanomoles/g dry retina for donors younger than 30 years of age and 24+/-13 ...

conclusions the effect of coadministration of nac and coq10 was neither additive nor synergic in protecting against nihl. results the temporary hearing changes that occurred 1-day post exposure were not significantly different in all groups (p > 0.05). the total recovery (between 1 - 21 days after noise exposure) varied by a frequency increase between 1.08 - 19.10 in the noise group compared to...