Endornaviruses have large double-stranded RNA (dsRNA) genomes that carry a single open reading frame (ORF). Here we report the complete genome of a novel endornavirus, assembled from next-generation sequence data generated from Vitis vinifera-extracted dsRNA. Two different fungal hosts have been identified for this virus, suggesting that horizontal transmission of the virus is possible.

Cognitive models of reading predict that high frequency regular words can be read in more than one way. We investigated this hypothesis using functional MRI and covariance analysis in 43 healthy skilled readers. Our results dissociated two sets of regions that were differentially engaged across subjects who were reading the same familiar words. Some subjects showed more activation in left infer...

Low prevalence studies show that people miss a large proportion of targets if they appear rarely. This finding has implications for real-world tasks, such as mammography, where it is important to detect infrequently appearing cancers. We examined whether having search in pairs double reading procedure reduces errors low compared with when participants the displays alone. In Experiment 1 searche...

Murine double minute clone 2 (MDM2), p14 alternate reading frame (p14arf), and nucleophosmin (NPM) regulate p53 activity. A total of 200 biopsies, including normal bronchial, pre-invasive and invasive tissues, were examined for changes in NPM, p14arf, MDM2 and p53 expression patterns by immunohistochemistry and immunofluorescence with confocal microscopy. NPM and p14arf displayed a diffuse nucl...

In the analysis by Brown and colleagues that compared the current rnammography reading policy at St. Margaret's Hospital (double reading with consensus required for recall) with 2 alternative hypothetical strategies, the authors showed that the current strategy used is the most cost-effective. 2 elements of this study must he considered when attempting to generalise the conclusions to other set...

In the analysis by Brown and colleagues that compared the current rnammography reading policy at St. Margaret's Hospital (double reading with consensus required for recall) with 2 alternative hypothetical strategies, the authors showed that the current strategy used is the most cost-effective. 2 elements of this study must he considered when attempting to generalise the conclusions to other set...