The global prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to be around 30%,1 with its burden expected increase over time. Assessment hepatic steatosis (HS) currently done in a semi-quantitative manner by histopathologists and subject intra- inter-observer variability. Artificial intelligence (AI) algorithms applied the identification quantification has advantage increasing...

OBJECTIVES/HYPOTHESIS Plasma Epstein-Barr virus (EBV) DNA concentrations predict prognosis in patients with nasopharyngeal carcinoma (NPC). Recent evidence also indicates that intratumor heterogeneity on F-18 fluorodeoxyglucose positron emission tomography (18 F-FDG PET) scans is predictive of treatment outcomes in different solid malignancies. Here, we sought to investigate the prognostic valu...

Xenotransplantation of porcine fetal ventral mesencephalic (pfVM) cells to overcome the dopamine shortage in the striatum of patients with Parkinson's disease seems a viable alternative to allotransplantion of human fetal donor tissue, especially because the latter is complicated by both practical and ethical issues. There is, however, little known about the xenospecific immune responses involv...

Protein mimicry of DNA is a recently discovered direct mechanism of regulation of DNAdependent enzyme activity by means of proteins that mimic DNA structure and interact with a target enzyme and completely inhibit (or modulate) its activity. DNA-mimicking inhibitor proteins bind directly to the enzyme and thus blocks or alters the activity of the latter. Protein mimicry of DNA was first describ...

The mature striatum is divided into a labyrinthine system of striosomes embedded in a surrounding matrix compartment. We pulse-labeled striosomal cells (S cells) and matrix cells (M cells) in cats with (3) H-thymidine and followed their distributions during fetal and postnatal development. We identified three maturational phases in S-cell distributions. The early phase (sampled at embryonic day...

Plasmid pAD1 is a 60-kb conjugative element commonly found in clinical isolates of Enterococcus faecalis. The relaxase TraX and the primary origin of transfer oriT2 are located close to each other and have been shown to be essential for conjugation. The oriT2 site contains a large inverted repeat (where the nic site is located) adjacent to a series of short direct repeats. TraX does not show an...

the initial step in any breeding program including the breeding of walnut is an evaluation of the genetic diversity of its population and on identification of its superior and promising genotypes. this research was carried out during 2009-2010 growing seasons to evaluate the walnut genotypes, population grown in the vicinities of eghlid city, as one of the richest walnut population regions in t...

1 Fanburg-Smith JC, Michal M, Partanen TA, Alitalo K, Miettinen M. Papillary intralymphatic angioendothelioma (PILA): a report of twelve cases of a distinctive vascular tumor with phenotypic features of lymphatic vessels. Am J Surg Pathol 1999; 23: 1004–1010. 2 McKee PH, Calonje E, Grantner SR, eds. Pathology of the Skin, 3rd edn. Elsevier Mosby, London, 2005: 1829–1830 3 Weedon D. Weedon’s Ski...