Answers to questions about frequency and repertoire of immune cells, relative contributions made by different types of immune cells toward the total EpsteinBarr virus (EBV)–directed response and the variation of such responses in healthy persons have been elusive because of disparities in assays, antigen presenting cells, and antigenic sources used in previous experiments. In this study, we add...

A 79 year-old Caucasian man presented to our institution with jaundice and dark urine having fallen from a ladder in his stables three days prior to admission. The fall had left him with some discomfort for which he had self-medicated with paracetamol. He denied having exceeded the recommended dose of paracetamol. There was no past medical history of liver disease, illicit drug use, drugs known...

The role of viral infection in bronchial asthma (BA) is well-known being reflected particularly GINA. An effect pneumotropic intracellular persistent herpesviruses on the course BA particular interest. most common viruses this group are cytomegalovirus (CMV), EpsteinBarr virus (EBV), and human herpesvirus 6 (HHV-6). CMV has been discussed our previous publications allowing us to focus here EBV ...

Topicality: The chronic nasopharyngitis (CNP) morbidity rate tends to increase in childhood and adenoid removal is one of the most common all surgeries children. state nasopharyngeal microbiome plays significant role development inflammatory processes nasopharynx hypertrophy it considered that great progress can be made through its correction conservative treatment prevention recurrence after s...

Evans, D. I. K. (1973). Archives of Disease in Childhood, 48, 441. Immune response in families of children with acute lymphoblastic leukaemia. The immune status of 33 mothers, 17 fathers, and 14 sibs of children with acute lymphoblastic leukaemia was studied with the following tests: peripheral blood lymphocyte counts, lymphocyte transformation with phytohaemagglutinin, serum immunoglobulin lev...

Sequence-specific recognition of DNA by proteins is essential for both transcription and DNA replication. Transcription factors form a growing family of regulatory proteins that can positively or negatively influence transcription by binding to regulatory elements in DNA contacting components of the basal transcription machinery. In recent years, it has become clear that several transcription f...

To the Editor—We read with interest Chan et al’s report on haemophagocytic lymphohistiocytosis (HLH) in Hong Kong children.1 Of their seven cases, none was classified as primary HLH but limited by unavailability of molecular testing. No malignancy or connective tissue disease was found. Two of seven were confirmed by serology testing to have EpsteinBarr virus (EBV)–associated HLH. The mean time...

Miranda M, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220523 Description A 3-year-old boy, with no relevant family/personal history, presented at the emergency department due to recurrent left hemifacial erythematous oedema and feverish peak. The mother reported two similar episodes in the previous months, interpreted as periorbital cellulitis, with resolution with systemic antibiotic and o...