BACKGROUND Cytochrome P450 2C19 (CYP2C19) is important in metabolism of wide range of drugs. CYP2C19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (URM). Distribution of this variant allele has not been well studied worldwide. The aim of present study was to investigate allele and genotype frequencies of CYP2C19*17 in ...

the objective of the present study was to detect polymorphism in follicle stimulating hormone receptor (fshr) and beta subunit of follicle stimulating hormone (fshβ) genes and their relation to litter size and body weight trait in baluchi, iran black and arman sheep breeds. pcr-rflp technique using acci and hinfi enzyme treatments employed to detection of polymorphism in fshβ marker site but de...

genetic improvement programs may improve disease resistance in animal production. the best-characterized genetic control of disease resistance and immune response in animals is the one associated with the major histocompatibility complex (mhc). the ovine lymphocyte antigenof drb1 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to...

In the present study, we report mitochondrial DNA (mtDNA) 16S rRNA gene sequence analysis of Morkaraman ewe, (Ovis aries) was investigated. domestic sheep, is ca 1574 bp in length. Partial fragment 536 mtDNA amplified by using designed primers from published data Sheep sequences derived National Center for Biotechnology Information (NCBI) web server (ncbi.nlm.nih.gov/NC_001941.1). Homology obta...

the purpose of the study was to detect the alui and ddei polymorphisms within pou1f1 gene exon 6 and 3'utr region in turkish sheep breeds, and their association with milk productive traits. jugular blood samples were collected from 50 sakiz, 50 white karaman, and 50 awassi sheep using edta as an anticoagulant. pcr-rflp and sequencing analysis were performed to investigate possible polymorphisms...

aim : this study aimed to determinant association between rs76189946 polymorphism of egf gene and risk of colorectal cancer in an iranian population. background : colorectal cancer (crc) is the third most prevalent cancer in both genders worldwide. the determination of genetic variation becomes a new way to etiology of colorectal cancer. epidermal growth factor (egf) is a mitogen that plays an ...

AIM This study aimed to determinant association between rs76189946 polymorphism of EGF gene and risk of colorectal cancer in an Iranian population. BACKGROUND Colorectal cancer (CRC) is the third most prevalent cancer in both genders worldwide. The determination of genetic variation becomes a new way to etiology of colorectal cancer. Epidermal growth factor (EGF) is a mitogen that plays an im...

the diacylglycerol acyltransferase 1 gene (dgat1) was identified as a strong candidate gene affecting mutton quality traits in sheep. single nucleotide polymorphism creates a single base mutation (c to t) in agct site of endonuclease alui. dgat1 is one of the candidate genes to improve carcass characteristics in feedlot animals. in order to study area t487c in exon 17 of the dgat1 polymorphism,...