An 18 year old woman with congenital hemihypertrophy of her left side, presented with the rapid onset of virilism, hypertension and a cushingoid appearance. A computed tomographic examination revealed adrenal and hepatic masses. Adrenocortical carcinoma was confirmed by surgical pathology. Hemihypertrophy is linked to a variety of benign and malignant disorders that usually appear during childh...

1 HIRSUTISM, VIRILISM, POLYCYSTIC OVARIAN DISEASE AND STEROID2 3 GONADOTROPIN-FEEDBACK SYSTEM: A CAREER RETROSPECTIVE 4 5 6 7 8 9 10 11 12 Virendra B. Mahesh, 13 14 Department of Physiology and Endocrinology, 15 16 Medical College of Georgia (Now Georgia Health Sciences University), 17 18 1120 15 Street, Augusta Georgia 30912. 19 20 21 22 23 24 25 Running title: Steroid-gonadotropin-feedback sy...

t is the purpose of this paper to contribute to the discussion initiated bywachter about the parallelism between principal component (pc) and atypological grade of membership (gom) analysis. the author testedempirically the close relationship between both analysis in a lowdimensional framework comprising up to nine dichotomous variables and twotypologies. our contribution to the subject is also...

Mariana Tomé Fernández-Ladreda , Guillermo Martínez de Pinillos Gordillo , Francisco Pichardo López de Haro, María Victoria Cózar León a a Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario de Valme, Área de Gestión Sanitaria Sur de Sevilla, Sevilla, Spain b Servicio de Anatomía Patológica, Hospital Universitario de Valme, Área de Gestión Sanitaria Sur de Sevilla, S...

Hyperostosis frontalis interna is an unexplained irregular thickening of the inner table of the frontal bone. Hyperostosis frontalis interna was first identified in 1719 by Morgagni as a symptom of a more generalized syndrome characterized by virilism and obesity. Most current studies have shown hyperostosis frontalis interna to be a sex- and age-dependent phenomenon, and females manifest a sig...

An interstitial cell tumour of the testis produces a characteristic clinical picture. Starting between the ages of 2 and 6 years, the boy develops macrogenitosomia praecox with a raised excretion of urinary 17-ketosteroids. The tumour, which is usually unilateral and non-malignant, may not be obvious initially. Occasionally there is gynaecomastia. Penile erections are frequent. The behaviour ra...