Acute lung injury (ALI) is identified with the targeting/sequestration of polymorphonuclear leukocytes (PMN) to the lung. Instrumental to PMN targeting are chemokines [e.g., macrophage inflammatory protein-2 (MIP-2), keratinocyte-derived chemokine (KC), etc.] produced by macrophage, PMN, and other resident pulmonary cells. However, the relative contribution of resident pulmonary macrophages as ...

the direct way to access the petrophysical property of hydrocarbon reservoir is based on well data but due to its high cost, the seismic data has been used to obtain these parameters. for this purpose, many different methods are available and each has its own advantages and limitations. from these methods the seismic inversion is the best tool to study the reservoir characterization. the outcom...

seismic inversion is a method that extracts acoustic impedance data from the seismic traces. sourcewavelets are band-limited, and thus seismic traces do not contain low and high frequency information.therefore, there is a serious problem when the deterministic seismic inversion is applied to real dataand the result of deterministic inversion is smooth. low frequency component is obtained from w...

The cortical hem, a source of Wingless-related (WNT) and bone morphogenetic protein (BMP) signaling in the dorsomedial telencephalon, is the embryonic organizer for the hippocampus. Whether the hem is a major regulator of cortical patterning outside the hippocampus has not been investigated. We examined regional organization across the entire cerebral cortex in mice genetically engineered to la...

One of the most remarkable basis of the gravity data inversion is the recognition of sharp boundaries between an ore body and its host rocks during the interpretation step. Therefore, in this work, it is attempted to develop an inversion approach to determine a 3D density distribution that produces a given gravity anomaly. The subsurface model consists of a 3D rectangular prisms of known sizes ...

Cho and Lee (2004) proposed a Bayesian hierarchical error model (HEM) to account for heterogeneous error variability in oligonucleotide microarray experiments. They estimated the parameters of their model using Markov Chain Monte Carlo (MCMC) and proposed an F-like summary statistic to identify differentially expressed genes under multiple conditions. Their HEM is one of the emerging Bayesian h...

The purpose of this paper is twofold: to describe the water quality model of Three-Dimensional Hydrodynamic-Eutrophication Model (HEM-3D) and to present an application of HEM-3D to a coastal system in Korea. HEM-3D, listed as a tool for the development of Total Maximum Daily Load by US Environmental Protection Agency, is a general-purpose modeling package for simulation of the flow field, trans...

In chronic myelogenous leukemia (CML), the development of chromosomal abnormalities in addition to the Philadelphia chromosome (clonal evolution) is considered by many to be a feature of accelerated phase (AP). Imatinib mesylate (STI571), a selective inhibitor of the Bcr-Abl tyrosine kinase, has significant activity in AP CML. As clonal evolution could allow Bcr-Abl independent proliferation, w...