Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC). Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with tumor node metastasis (TNM) staging of BC patients. Functional enrichment analysis was conducted to functionally annotate the hub genes. Protei...

    Hub covering location problem, Network design,   Single machine scheduling, Genetic algorithm,   Shuffled frog leaping algorithm   Hub location problems (HLP) are synthetic optimization problems that appears in telecommunication and transportation networks where nodes send and receive commodities (i.e., data transmissions, passengers transportation, express packages, postal deliveries, etc....

The hub location problem is employed for many real applications, including delivery, airline and telecommunication systems and so on. This work investigates on hierarchical hub network in which a three-level network is developed. The central hubs are considered at the first level, at the second level, hubs are assumed which are allocated to central hubs and the remaining nodes are at the third ...

This paper uses the energy hub concept to meet the water, heat and electricity demand of a power plant in the Qeshm island in south of Iran. Given the power plant’s high potential for waste heat recovery and some scenarios were considered using the hub energy concept based on energy, exergy, environmental and economic analyzes in terms of meeting the demands of the hub and purchasing/selling en...

In this paper, a stochastic programming approach is applied to the airline network revenue management problem. The airline network with the arc capacitated single hub location problem based on complete–star p-hub network is considered. We try to maximize the profit of the transportation company by choosing the best hub locations and network topology, applying revenue management techniques to al...

the hub location decision is a long term investment and any changes in it take considerable time and money. in real situations, some parameters are uncertain hence, deterministic models cannot be more efficient. the ability of two-stage stochastic programming is to make a long-term decision by considering effects of it in short term decisions simultaneously. in the two-stage stochastic programm...

this paper proposes a new mathematical model for designing and planning postal parcels carriage and postal networks. the objective of postal network designing is to determine the location, size and connection between the postal stations in a city, province or country. in this paper, a kind of multiple locations-allocations hub problem with limited capacity in collecting, distributing and broadc...

In this paper, we consider the design of large-scale hub-and-spoke transportation networks in a competitive environment. We adopt the hub arc location model that locates arcs with discounted transport costs connecting pairs of hub facilities. Two firms compete for passengers in a Stackelberg framework where the leader firm locates hub arcs to maximize its revenue, given that the follower firm w...

We consider the hub location problem, where p hubs are chosen from a given set of nodes, each nonhub node is connected to exactly one hub and each hub is connected to a central hub. Links are installed on the arcs of the resulting network to route the traffic. The aim is to find the hub locations and the connections to minimize the link installation cost. We propose two formulations and a heuri...