s of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando, FL. Washington, DC, American Society for Microbiology, 1994, p 266 (abstr H76) 148. Masucci G, Wersäll P, Ragnhammar P, Mellstedt H: Granulocytemonocyte-colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody dependent cellular cytotoxicity. Cancer Immunol Immunoth...

s of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando, FL. Washington, DC, American Society for Microbiology, 1994, p 266 (abstr H76) 148. Masucci G, Wersäll P, Ragnhammar P, Mellstedt H: Granulocytemonocyte-colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody dependent cellular cytotoxicity. Cancer Immunol Immunoth...

The mononuclear phagocyte system, particularly dendritic cells, plays several pivotal roles in the development of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Here, we demonstrate that functionally distinct dendritic cell subpopulations are present in the central nervous system during experimental autoimmune encephalomyelitis. At peak experimental autoimmu...

Highly purified murine granulocyte-macrophage progenitor cells (CFU-GM) were used as target cells to assess the possible direct effects of purified preparations of recombinant murine 7-intcrferon, prostaglandin E, recombinant human heavy chain (acidic) ferritin, and recombinant human tumor necrosis factor a (TNF-a) on progenitor cells in vitro. Target CFU-GM, with cloning efficiencies of up to ...

The biotechnology industry has established itself as a major source of new human therapeutic protein drugs which can be described as complex biological entities. The majority of these in production, such as erythropoeitin (EPO), interleukin-2 (IL-2), interferon (IFN), granulocyte colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor (GM-CSF) and tissue plasminogen ...

Macrophage-colony stimulating factor (M-CSF) has well-known effects on murine bone marrow, but its colony stimulating activity for human bone marrow is controversial. After treatment of human bone marrow with L-phenylalanine methylester (PME), macrophage-colonies (CFU-M) were induced by M-CSF in a dose-dependent fashion. The optimal concentration of recombinant human-macrophage colony stimulati...