The immune microenvironment in colorectal cancer (CRC) has a huge impact on progression. Among the consensus molecular subtypes (CMS) of CRC, CMS1 and CMS4 are both characterized with infiltrates, yet is considered to have good prognosis while opposite. Although CRC subtyping been useful way characterizing manifestations this heterogenous disease, contributions microbiome seldom discussed. We a...

In the present study the protective effect of Nigella sativa (N. sativa)on synaptic plasticity impairment induced by lipopolysaccharide (LPS) in rats was investigated. Fifty-eight rats were grouped and treated as follows: 1) control (saline), 2) LPS, 3) LPS-N. sativa,and 4) N. sativa. In a Morris water maze test, the escape latency and traveled path to find t...

Abstract Although propolis has been reported for having anti-inflammatory activities, its effects on complement system not much studied. This research was conducted to find out the of Indonesian expression levels C3, C1r/s, Bf, MBL, and C6 in zebrafish larvae which were induced by lipopolysaccharide (LPS). Counting macrophages migrating yolk sac liver histology carried out. Larvae divided into ...

Introduction: The central mechanism related to the cardiovascular response to lipopolysaccharide (LPS)-induced hypotension is not entirely known, but it is suggested that numerous brain areas such as dorsal periaqueductal gray (dPAG) are involved in this process. In the current work, the cardiovascular effect of the dPAG during LPS-induced hypotension is investigated. Methods: The study animal...

objective(s): we aimed to investigate the influence of transient receptor potential channel 3 (trpc3) on lipopolysaccharide-induced (lps) preterm delivery mice. materials and methods: mice were randomly assigned to the four groups: an unpregnant group, a mid-pregnancy group (e15), a term delivery group, and an lps-induced preterm delivery group (intraperitoneal injection lps at 15 days). uterin...

Abstract Selenomethionine (SeMet) is a widely used food supplement. However, the research on effect of SeMet intestinal immune function not enough. Therefore, in this experiment, was added to diet chickens, and lipopolysaccharide (LPS) as harmful stimulation study chickens. We chose chicken jejunum object. The results showed that LPS treatment decreased expressions selenoproteins induced inflam...

Neuro-immune mediators play an important role in the development of sickness behaviors. In the present study, the effect of captopril on sickness behaviors caused by lipopolysaccharide (LPS) was studied in the rats. The animals were randomized into the following groups: control, sham, 10 mg kg-1 captopril - LPS (Capto 10-LPS), 50 mg kg-1 captopril - LPS (Capto 50-LPS), and...

Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate effect of PRDX1 on EMT airway epithelial cells stimulated with lipopolysaccharide (LPS) transforming growth factor-beta (TGF-β1). overexpression significantly increased proliferation migration human bronchial (BEAS-...

Lipopolysaccharide (LPS) was used to induce neuroinflammation in rats and the expression of brain cyclooxygenase-2 (COX-2) is marker for process [1]. The effect minocycline on neuroinflammation-induced LPS not clearly elucidated.
 
 objective this study determine effects (MIN) LPS-induced COX-2 compared it with a clinically approved drug Alzheimer’s disease named memantine. A total fi...