Background: Acetaminophen is a popular antipyretic and analgesic medication worldwide; however, its therapeutic window narrow, which may lead to overdose or toxicity. This study was conducted assess the correlation between serum acetaminophen levels before 4 hours after acute toxicity with this drug. The objective of test validity level arrive at clinical decision on acetaminophen. Methods: cro...

objective: this study aimed to investigate the effects of royal jelly (rj) on catalase, total antioxidant capacity and embryo development in adult mice treated with oxymetholone (oxm). materials and methods: in this exprimental study, 32 male and 96 female adult naval medical research institute (nmri) mice (7-9 weeks of age) with a ratio of 1:3 for fertilization purposes were randomly divided i...

pioglitazone (pg) is one of thiazolidinediones used for the treatment of type ii diabetes mellitus. some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. in the present study, the protective effect of some atp suppliers are investigated against mitochondrial toxicity of pg in isolated rat mitochondria. mitochondrial viability was investigated by mt...

Diastereoselective formal synthesis of a monoterpene alkaloid, (-)-incarvilline, the key intermediate for the synthesis of (-)-incarvillateine, was achieved by using an intramolecular Pauson-Khand reaction of (S)-N-[(E)-2-butenyl]-N-(3-butynyl-2-methoxymethoxy)-p-toluenesulfonamide as a key step.

N-substituted aromatics are important priority pollutants entering the environment primarily through anthropogenic activities associated with the industrial production of dyes, explosives, pesticides, and pharmaceuticals. Anaerobic treatment of wastewaters discharged by these industries could potentially be problematical as a result of the high toxicity of N-substituted aromatics. The objective...

the current study evaluated the general toxicity, antioxidant, antimicrobial, and cytotoxic activity of extracts obtained from the rhizomes of eremostachys azerbaijanica (labiatae) as well as analyzed the potent extracts using gc-ms. extracts of e. azerbaijanica in n-hexane, dichloromethane (dcm) and methanol (meoh) were prepared using a soxhlet apparatus. the antioxidant activity of the extrac...

THEORETICAL AND EXPERIMENTAL STUDY OF STRUCTURE REACTIVITY RELATED TO METABOLISM TOXICITY PARACETAMOL. An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, chemical reactivity using frontier orbitals Fukui index were used explaining main p...