Females are born with a finite number of primordial follicles. 4-Vinylcyclohexene diepoxide (VCD) is a metabolite formed by epoxidation of 4-vinylcyclohexene (VCH) via its two monoepoxides 1,2- and 7,8-4-vinylcyclohexene monoepoxide (VCM). VCD specifically destroys small preantral (primordial and small primary) follicles in the rodent ovary. The phase I enzyme, cytochrome P450 isoform 2E1 (CYP2...

The hole transport properties of poly(2-methoxy, 5-(2'-ethyl-hexoxy)-p-phenylene vinylene) (MEH-PPV) blended with acid oxidized multiwall carbon nanotubes (COOH-MWCNTs) were investigated in a diode configuration using the time-of-flight (TOF) photocurrent method. While the room temperature hole mobility in pure MEH-PPV films was non-dispersive with positive field dependent mobility, MEH-PPV:COO...

The effects of acriflavine (ACF), a protein kinase C inhibitor, on the expression of hepatic microsomal epoxide hydrolase (mEH), glutathione S-transferases (GSTs), and cytochrome P450 (P450) were assessed in rat hepatic tissue. Northern blot analysis revealed that treatment of rats with thiazole, allyl disulfide (ADS), oltipraz, or clotrimazole at a single dose of 100 mg/kg resulted in 7-18-fol...

Interchain interactions in conjugated polymer films promote good carrier transport but also reduce the luminescence quantum yield, leading to a fundamental trade-off in optimizing film morphology for device performance. We present two methods to improve the efficiency of light-emitting diodes ~LEDs! based on poly~2-methoxy-5-~28-ethylhexyloxy!-1,4-phenylenevinylene! ~MEH-PPV! by altering film m...

Epidemiologic studies have implicated exposure to tobacco smoke and high intakes of cooked, broiled, or well-done meats in the increased risk of colorectal cancers (1-4). Microsomal epoxide hydrolase (mEH) is a phase II biotransformation enzyme which detoxifies epoxides, including carcinogens such as polycyclic aromatic hydrocarbons found in cigarette smoke and cooked meats (5). A tyrosine to h...

Recently, the conjugated polymer – inorganic nanocomposites have been increasingly studied due to the potential applications of these advanced materials in developing optoelectronic devices. In this work nanocomposite materials thin films based on poly [2-methoxy-5-(2’-ethyl-hexyloxy)-1,4-phenylene vinylene] (MEH-PPV) and nanocrystalline TiO2 (nc-TiO2) have been fabricated. The photoluminescenc...

Occupational exposure to endotoxin in organic dust may induce lung function decline. Microsomal epoxide hydrolase (mEH) detoxifies reactive oxygen species generated by endotoxin exposure, and polymorphisms of the mEH gene are associated with altered enzyme activity. We investigated the associations between mEH polymorphisms, endotoxin exposure, and lung function decline in a 20-year prospective...

OBJECTIVE To compare immunohistochemical estrogen receptor expression on formalin-fixed, paraffin-embedded breast carcinoma tissue sections by using regular, extended microwave heating and pressure cooker technique for heat induced antigen retrieval. STUDY DESIGN Quasi experimental study. PLACE AND DURATION OF STUDY Department of Histopathology, Armed Forces Institute of Pathology, Rawalpin...

Nuruk, which is a natural inoculator and source of amylolytic enzymes, is used in Korean traditional rice wine. A methanol extract of nuruk (NE) attenuated lipopolysaccharide (LPS)- induced nitrite and interleukin (IL)-6 in RAW 264.7 cells. Both the n-hexane and water fractions from NE (MEH and MW, respectively) inhibited the production of nitrite and IL-6 in RAW 264.7 cells. MEH and MW also in...